Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998294864> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1998294864 endingPage "4724" @default.
- W1998294864 startingPage "4720" @default.
- W1998294864 abstract "A series of 8-cyanopyrido[3',2':4,5]thieno[3,2-d]-1,2,3-triazines, substituted at C-4 and C-7, were synthesized and evaluated as nitric oxide and prostaglandin E(2) inhibitors in murine peritoneal macrophages stimulated with bacterial endotoxin. Several compounds exhibited considerable activity, compounds 10 and 13 being the most interesting ones with IC(50) values of 11.2 and 3.4 microM on nitrites and 0.9 and 0.6 microM on prostaglandin E(2) production, respectively. None of the examples of pyridothienotriazines that were active at 10 microM showed any effect on inducible nitric oxide synthase, cyclooxygenase-2, and cyclooxygenase-1 enzymes, suggesting that they act by modifiying the level of expression of these inducible enzymes." @default.
- W1998294864 created "2016-06-24" @default.
- W1998294864 creator A5011855262 @default.
- W1998294864 creator A5025374463 @default.
- W1998294864 creator A5055583796 @default.
- W1998294864 creator A5063242987 @default.
- W1998294864 creator A5068014083 @default.
- W1998294864 creator A5074492027 @default.
- W1998294864 creator A5074985725 @default.
- W1998294864 creator A5086012885 @default.
- W1998294864 date "1999-10-09" @default.
- W1998294864 modified "2023-09-24" @default.
- W1998294864 title "Synthesis and Pharmacological Evaluation of Some 8-Cyanopyrido[3‘,2‘:4,5]thieno[3,2-<i>d</i>]triazine Derivatives as Inhibitors of Nitric Oxide and Eicosanoid Biosynthesis" @default.
- W1998294864 cites W1600193814 @default.
- W1998294864 cites W1978038466 @default.
- W1998294864 cites W1980528903 @default.
- W1998294864 cites W1988806198 @default.
- W1998294864 cites W2004552308 @default.
- W1998294864 cites W2105821269 @default.
- W1998294864 cites W2140174751 @default.
- W1998294864 cites W2149200346 @default.
- W1998294864 doi "https://doi.org/10.1021/jm991085l" @default.
- W1998294864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10579834" @default.
- W1998294864 hasPublicationYear "1999" @default.
- W1998294864 type Work @default.
- W1998294864 sameAs 1998294864 @default.
- W1998294864 citedByCount "17" @default.
- W1998294864 countsByYear W19982948642012 @default.
- W1998294864 crossrefType "journal-article" @default.
- W1998294864 hasAuthorship W1998294864A5011855262 @default.
- W1998294864 hasAuthorship W1998294864A5025374463 @default.
- W1998294864 hasAuthorship W1998294864A5055583796 @default.
- W1998294864 hasAuthorship W1998294864A5063242987 @default.
- W1998294864 hasAuthorship W1998294864A5068014083 @default.
- W1998294864 hasAuthorship W1998294864A5074492027 @default.
- W1998294864 hasAuthorship W1998294864A5074985725 @default.
- W1998294864 hasAuthorship W1998294864A5086012885 @default.
- W1998294864 hasConcept C114373084 @default.
- W1998294864 hasConcept C178790620 @default.
- W1998294864 hasConcept C181199279 @default.
- W1998294864 hasConcept C185592680 @default.
- W1998294864 hasConcept C202751555 @default.
- W1998294864 hasConcept C2776352991 @default.
- W1998294864 hasConcept C2776980637 @default.
- W1998294864 hasConcept C2777622882 @default.
- W1998294864 hasConcept C2778078955 @default.
- W1998294864 hasConcept C2779689624 @default.
- W1998294864 hasConcept C2780664492 @default.
- W1998294864 hasConcept C519581460 @default.
- W1998294864 hasConcept C553450214 @default.
- W1998294864 hasConcept C55493867 @default.
- W1998294864 hasConcept C71924100 @default.
- W1998294864 hasConcept C98274493 @default.
- W1998294864 hasConceptScore W1998294864C114373084 @default.
- W1998294864 hasConceptScore W1998294864C178790620 @default.
- W1998294864 hasConceptScore W1998294864C181199279 @default.
- W1998294864 hasConceptScore W1998294864C185592680 @default.
- W1998294864 hasConceptScore W1998294864C202751555 @default.
- W1998294864 hasConceptScore W1998294864C2776352991 @default.
- W1998294864 hasConceptScore W1998294864C2776980637 @default.
- W1998294864 hasConceptScore W1998294864C2777622882 @default.
- W1998294864 hasConceptScore W1998294864C2778078955 @default.
- W1998294864 hasConceptScore W1998294864C2779689624 @default.
- W1998294864 hasConceptScore W1998294864C2780664492 @default.
- W1998294864 hasConceptScore W1998294864C519581460 @default.
- W1998294864 hasConceptScore W1998294864C553450214 @default.
- W1998294864 hasConceptScore W1998294864C55493867 @default.
- W1998294864 hasConceptScore W1998294864C71924100 @default.
- W1998294864 hasConceptScore W1998294864C98274493 @default.
- W1998294864 hasIssue "22" @default.
- W1998294864 hasLocation W19982948641 @default.
- W1998294864 hasLocation W19982948642 @default.
- W1998294864 hasOpenAccess W1998294864 @default.
- W1998294864 hasPrimaryLocation W19982948641 @default.
- W1998294864 hasRelatedWork W1990842025 @default.
- W1998294864 hasRelatedWork W1998294864 @default.
- W1998294864 hasRelatedWork W2035949096 @default.
- W1998294864 hasRelatedWork W2049255613 @default.
- W1998294864 hasRelatedWork W2064969264 @default.
- W1998294864 hasRelatedWork W2091494117 @default.
- W1998294864 hasRelatedWork W2091814299 @default.
- W1998294864 hasRelatedWork W2116495306 @default.
- W1998294864 hasRelatedWork W2165501377 @default.
- W1998294864 hasRelatedWork W2168809949 @default.
- W1998294864 hasVolume "42" @default.
- W1998294864 isParatext "false" @default.
- W1998294864 isRetracted "false" @default.
- W1998294864 magId "1998294864" @default.
- W1998294864 workType "article" @default.