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• W1998301365 abstract "A conventional and easy method to establish a murine oral candidiasis model, which has not only a stable yeast population in the oral cavity but also symptoms characteristic of oral thrush, was developed by using a sedative agent. Mice were immunosuppressed with prednisolone and were given tetracycline hydrochloride. They were orally infected with 10(6) viable cells of Candida albicans by means of a cotton swab and enough chlorpromazine chloride had been injected to keep them in a sedative state about for 3 hr after inoculation. From day 3 to day 7 post inoculation, 10(5)-10(6) colony forming units of Candida were recovered from the oral cavity of each mouse and whitish, curd-like patches were observed on most parts of tongue. Microscopically, germ tubes had appeared on the tongue surface. This model would be a useful experimental oral candidiasis for investigating the pathogenesis of C. albicans oral infection and the efficacy of various antifungal agents microbiologically and symptomatically." @default.
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• W1998301365 date "2003-05-01" @default.
• W1998301365 modified "2023-10-01" @default.
• W1998301365 title "A Novel Murine Model of Oral Candidiasis with Local Symptoms Characteristic of Oral Thrush" @default.
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• W1998301365 doi "https://doi.org/10.1111/j.1348-0421.2003.tb03403.x" @default.
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