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- W1998302810 endingPage "3790" @default.
- W1998302810 startingPage "3790" @default.
- W1998302810 abstract "Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic, progressive and disabling disorders. Over the last few decades, new therapeutic approaches have been introduced which have led not only to a reduction in the mortality rate but also offered the possibility of a favorable modification in the natural history of IBD. The identification of clinical, genetic and serological prognostic factors has permitted a better stratification of the disease, thus allowing the opportunity to indicate the most appropriate therapy. Early treatment with immunosuppressive drugs and biologics has offered the opportunity to change, at least in the short term, the course of the disease by reducing, in a subset of patients with IBD, hospitalization and the need for surgery. In this review, the crucial steps in the natural history of both UC and CD will be discussed, as well as the factors that may change their clinical course. The methodological requirements for high quality studies on the course and prognosis of IBD, the true impact of environmental and dietary factors on the clinical course of IBD, the clinical, serological and genetic predictors of the IBD course (in particular, which of these are relevant and appropriate for use in clinical practice), the impact of the various forms of medical treatment on the IBD complication rate, the role of surgery for IBD in the biologic era, the true magnitude of risk of colorectal cancer associated with IBD, as well as the mortality rate related to IBD will be stressed; all topics that are extensively discussed in separate reviews included in this issue of World Journal of Gastroenterology." @default.
- W1998302810 created "2016-06-24" @default.
- W1998302810 creator A5026242246 @default.
- W1998302810 date "2012-01-01" @default.
- W1998302810 modified "2023-09-23" @default.
- W1998302810 title "Crucial steps in the natural history of inflammatory bowel disease" @default.
- W1998302810 cites W1493105068 @default.
- W1998302810 cites W1542309314 @default.
- W1998302810 cites W1597945029 @default.
- W1998302810 cites W1905191652 @default.
- W1998302810 cites W1932727195 @default.
- W1998302810 cites W1965370900 @default.
- W1998302810 cites W1968809716 @default.
- W1998302810 cites W1971404276 @default.
- W1998302810 cites W1971488788 @default.
- W1998302810 cites W1974442963 @default.
- W1998302810 cites W1975452204 @default.
- W1998302810 cites W1981194531 @default.
- W1998302810 cites W1983745537 @default.
- W1998302810 cites W1984426896 @default.
- W1998302810 cites W1984797402 @default.
- W1998302810 cites W1986937201 @default.
- W1998302810 cites W1987210645 @default.
- W1998302810 cites W1996139830 @default.
- W1998302810 cites W1999395941 @default.
- W1998302810 cites W2000683024 @default.
- W1998302810 cites W2001187233 @default.
- W1998302810 cites W2001478781 @default.
- W1998302810 cites W2003106549 @default.
- W1998302810 cites W2004301008 @default.
- W1998302810 cites W2005855936 @default.
- W1998302810 cites W2007406330 @default.
- W1998302810 cites W2008497900 @default.
- W1998302810 cites W2009678756 @default.
- W1998302810 cites W2011756150 @default.
- W1998302810 cites W2015629841 @default.
- W1998302810 cites W2017466857 @default.
- W1998302810 cites W2018268099 @default.
- W1998302810 cites W2019704003 @default.
- W1998302810 cites W2028876048 @default.
- W1998302810 cites W2029170128 @default.
- W1998302810 cites W2029607349 @default.
- W1998302810 cites W2029723826 @default.
- W1998302810 cites W2031471616 @default.
- W1998302810 cites W2032344676 @default.
- W1998302810 cites W2033164113 @default.
- W1998302810 cites W2041446227 @default.
- W1998302810 cites W2041606152 @default.
- W1998302810 cites W2041888440 @default.
- W1998302810 cites W2046313504 @default.
- W1998302810 cites W2047208232 @default.
- W1998302810 cites W2049897663 @default.
- W1998302810 cites W2051475647 @default.
- W1998302810 cites W2055461186 @default.
- W1998302810 cites W2056485500 @default.
- W1998302810 cites W2056873984 @default.
- W1998302810 cites W2057618464 @default.
- W1998302810 cites W2058595460 @default.
- W1998302810 cites W2058788523 @default.
- W1998302810 cites W2059127937 @default.
- W1998302810 cites W2061201686 @default.
- W1998302810 cites W2062405047 @default.
- W1998302810 cites W2062597435 @default.
- W1998302810 cites W2064991313 @default.
- W1998302810 cites W2070299891 @default.
- W1998302810 cites W2070414885 @default.
- W1998302810 cites W2081702816 @default.
- W1998302810 cites W2083759302 @default.
- W1998302810 cites W2088360186 @default.
- W1998302810 cites W2088826436 @default.
- W1998302810 cites W2090549398 @default.
- W1998302810 cites W2090685459 @default.
- W1998302810 cites W2092875173 @default.
- W1998302810 cites W2095540389 @default.
- W1998302810 cites W2096149726 @default.
- W1998302810 cites W2097183141 @default.
- W1998302810 cites W2097733438 @default.
- W1998302810 cites W2098249583 @default.
- W1998302810 cites W2100757339 @default.
- W1998302810 cites W2102087425 @default.
- W1998302810 cites W2104164841 @default.
- W1998302810 cites W2105264433 @default.
- W1998302810 cites W2106733239 @default.
- W1998302810 cites W2109899118 @default.
- W1998302810 cites W2110431279 @default.
- W1998302810 cites W2111152018 @default.
- W1998302810 cites W2112907719 @default.
- W1998302810 cites W2115000032 @default.
- W1998302810 cites W2115865518 @default.
- W1998302810 cites W2118422544 @default.
- W1998302810 cites W2124929831 @default.
- W1998302810 cites W2124979919 @default.
- W1998302810 cites W2126807394 @default.
- W1998302810 cites W2128570249 @default.
- W1998302810 cites W2129828266 @default.
- W1998302810 cites W2130947879 @default.
- W1998302810 cites W2133792625 @default.
- W1998302810 cites W2133865474 @default.