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• W1998313557 abstract "The effects of insulin-like growth factor-1 (IGF-1) on the cytotoxicity and apoptosis induced by okadaic acid (OA) in SH-SY5Y cells were investigated. Cell viability was measured using the MTT (3-(4,5-dimethylthiazolyl-2)-2,-5-diphenyltetrazolium bromide) assay. Early and late apoptosis/necrosis were analyzed by flow cytometry using Annexin V and propidium iodide (PI) double-staining. Caspase-3 activation was detected by Western blot analysis. Preincubation with IGF-1 for 24 h prevented cytotoxicity induced by 40 nM OA given for 24 h, and the MTT value significantly increased. Incubation with 20 nM OA for 24 h caused a marked increase in the percentage of early apoptotic and late apoptotic/necrotic cells, which was not dependent on the activation of caspase-3. OA-induced apoptosis was significantly decreased by pretreatment with 10 ng/ml of IGF-1 for 24 h. The results supported the hypothesis that IGF-1 may be useful in the treatment of Alzheimer's disease." @default.
• W1998313557 created "2016-06-24" @default.
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• W1998313557 date "2005-09-01" @default.
• W1998313557 modified "2023-09-27" @default.
• W1998313557 title "Effects of insulin-like growth factor-1 on okadaic acid-induced apoptosis in SH-SY5Y cells" @default.
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• W1998313557 doi "https://doi.org/10.1016/j.cellbi.2005.04.012" @default.
• W1998313557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16087362" @default.
• W1998313557 hasPublicationYear "2005" @default.
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