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• W1998323190 endingPage "e19849" @default.
• W1998323190 startingPage "e19849" @default.
• W1998323190 abstract "Oligodendrocytes are the glial cells responsible for myelin formation. Myelination occurs during the first postnatal weeks and, in rodents, is completed during the third week after birth. Myelin ensures the fast conduction of the nerve impulse; in the adult, myelin proteins have an inhibitory role on axon growth and regeneration after injury. During brain development, oligodendrocytes precursors originating in multiple locations along the antero-posterior axis actively proliferate and migrate to colonize the whole brain. Whether the initial interactions between oligodendrocytes and neurons might play a functional role before the onset of myelination is still not completely elucidated. In this article, we addressed this question by transgenically targeted ablation of proliferating oligodendrocytes during cerebellum development. Interestingly, we show that depletion of oligodendrocytes at postnatal day 1 (P1) profoundly affects the establishment of cerebellar circuitries. We observed an impressive deregulation in the expression of molecules involved in axon growth, guidance and synaptic plasticity. These effects were accompanied by an outstanding increase of neurofilament staining observed 4 hours after the beginning of the ablation protocol, likely dependent from sprouting of cerebellar fibers. Oligodendrocyte ablation modifies localization and function of ionotropic glutamate receptors in Purkinje neurons. These results show a novel oligodendrocyte function expressed during early postnatal brain development, where these cells participate in the formation of cerebellar circuitries, and influence its development." @default.
• W1998323190 created "2016-06-24" @default.
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• W1998323190 date "2011-05-12" @default.
• W1998323190 modified "2023-10-15" @default.
• W1998323190 title "Oligodendrocytes as Regulators of Neuronal Networks during Early Postnatal Development" @default.
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• W1998323190 doi "https://doi.org/10.1371/journal.pone.0019849" @default.
• W1998323190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3093406" @default.
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