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- W1998327312 abstract "Abstract Mouse fibroblast (L-929) cells, in culture, synthesized and secreted into the growth medium a vitamin B12-binding substance which was identical to mouse transcobalamin II (TC II) as judged by the following criteria: (i) gel filtration on Sephadex G-200, (ii) ion-exchange chromatography on DEAE-cellulose and CM-cellulose, and (iii) the ability to facilitate cellular B12 uptake by L-929 cells. The secretion of mouse fibroblast binder was blocked by cycloheximide and puromycin; and in both cases the cells' ability to secrete this binder was partially restored when the inhibitor was removed. Within 30 h after the cells were exposed to [57Co]B12 bound to mouse serum TC II (Mr ~ 38,000) the [57Co]B12 was bound to a large molecular weight intracellular binder (Mr ~ 120,000) which was not released into the culture medium. During this same incubation period, the cells released free [57Co]B12 and [57Co]B12 bound to a protein which had the same elution volume as mouse serum TC II on Sephadex G-200." @default.
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- W1998327312 date "1976-10-01" @default.
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- W1998327312 title "Mouse transcobalamin II: Biosynthesis and uptake by L-929 cells" @default.
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- W1998327312 doi "https://doi.org/10.1016/0003-9861(76)90212-5" @default.
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