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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998333711> ?p ?o ?g. }

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• W1998333711 abstract "A multiparticulate delayed release system based on coated pellets containing an osmotic active ingredient is presented. The coating consists of a semipermeable membrane of cellulose acetate. After application water penetrates into the core and forms a saturated solution of the soluble components. The osmotic pressure gradient induces a water influx resulting in a rapid expansion of the membrane leading to the formation of pores. The osmotic ingredient and the drug are released through these pores according to a zero order kinetic. In comparison with the sodium chloride free formulation the inclusion of the osmotically active ingredient results in a completely different dissolution behavior. Lag time and dissolution rate are dependent on the coating level and the osmotic properties of the dissolution medium. However, the dissolution rate is sufficient even with high coating levels to obtain delayed release properties. The model proposed is supported by data from determination of pellet swelling behaviour, sodium chloride release, single pellet dissolution and release in media of different pH and osmolality." @default.
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• W1998333711 date "1997-08-01" @default.
• W1998333711 modified "2023-09-27" @default.
• W1998333711 title "A new multiparticulate delayed release system." @default.
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• W1998333711 doi "https://doi.org/10.1016/s0168-3659(97)01634-9" @default.
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