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- W1998342881 abstract "The relationship between the absorption-enhancing activity and binding power of intrinsic factor ( I.F. ) for vitamin B 12 was studied by the “intestinal loop” technique. Chromatography of a rat stomach mucosal extract with diethylaminoethyl cellulose yielded one vitamin B 12 -binding component. In spite of inhomogeneity of the component, I.F. activity was always associated and correlated quantitatively with the binding power. No I.F. activity was found in effluents without binding power. Absorption of 60 Co-vitamin B 12 was much greater when it was bound to the source of I.F. at the time of administration than when it was in a free form. The vitamin B 12 -binding power of the extract was heat-labile, and reduction in binding power resulted in a proportional loss of I.F. activity. A condition is also described which destroyed I.F. activity without cleaving the bond between I.F. and vitamin B 12 . Thus, conjugation of I.F. and vitamin B 12 represents an essential, though not the entire, process of the function of I.F. Another active site on the I.F. molecule, in addition to the one for binding vitamin B 12 , is postulated." @default.
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- W1998342881 date "1962-11-01" @default.
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- W1998342881 title "Binding of vitamin B12 by intrinsic factor and intestinal absorption" @default.
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- W1998342881 doi "https://doi.org/10.1016/0009-8981(62)90059-1" @default.
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