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- W1998348766 abstract "Abstract Studying the humoral immune response after influenza vaccination, with focus on the immune activity occurring locally at mucosal surfaces and in associated lymphoid tissue, provides a valuable tool for understanding immunity to influenza. Here we summarize our work addressing the kinetics of the local and the systemic immune responses after influenza vaccination in humans. Our studies have shown that inactivated influenza vaccine induced a rapid systemic immune response, which was associated with a local response in tonsils and oral fluid in healthy adults. However, the response in tonsils and oral fluid was impaired in young children (under 3 years old). The rapidity and the magnitude of the immune response did not seem to be impaired in diabetic patients and was not altered by treatment of healthy adults with the antiviral zanamivir. High frequencies of influenza-specific antibody secreting cells (ASC) were detected in nasal mucosa of healthy adults. However, parenteral vaccination did not induce an increase in frequency or the number of these ASC. Ongoing studies are investigating the characteristics of influenza-specific T- and B-cells induced locally and systemically after vaccination in man." @default.
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- W1998348766 date "2004-06-01" @default.
- W1998348766 modified "2023-09-27" @default.
- W1998348766 title "The kinetics of the systemic and local immune response to parenteral influenza vaccination" @default.
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- W1998348766 doi "https://doi.org/10.1016/j.ics.2004.02.151" @default.
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