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• W1998362112 abstract "<b>Background/aims:</b> The authors have previously reported that carbonic anhydrase inhibitors such as acetazolamide and dorzolamide raise optic nerve oxygen tension (ONPO₂) in pigs. The purpose of the present study was to investigate whether timolol, which belongs to another group of glaucoma drugs called β blockers, has a similar effect. In addition, the effect of dorzolamide and timolol in combination was studied. <b>Methods:</b> Polarographic oxygen electrodes were placed transvitreally over the optic disc in anaesthetised pigs and ONPO₂ was recorded continually. Drugs were administered intravenously either as 100 mg timolol followed by 500 mg dorzolamide (n = 5), 500 mg dorzolamide followed by 100 mg timolol (n = 5), or 100 mg timolol and 500 mg dorzolamide given simultaneously (n = 5). Arterial blood pressure, blood gasses, and heart rate were recorded. <b>Results:</b> ONPO₂ was unaffected by administration of 100 mg timolol as an intravenous injection (n = 5). Administration of 500 mg dorzolamide by itself significantly increased ONPO₂ from 2.96 (SD 0.62) kPa to 3.69 (SD 0.88) kPa (n = 4, p = 0.035). The dorzolamide induced ONPO₂ increase was not significantly different from the ONPO₂ increases were seen when dorzolamide was administered simultaneous with (n = 5) or 35 minutes (n = 5) after 100 mg timolol. <b>Conclusion:</b> Systemic administration of timolol does not affect the optic nerve oxygen tension despite its lowering effect on the intraocular pressure. Additionally, timolol does not affect the ONPO₂ increasing effect of dorzolamide." @default.
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• W1998362112 date "2004-02-01" @default.
• W1998362112 modified "2023-10-16" @default.
• W1998362112 title "Optic nerve oxygen tension: the effects of timolol and dorzolamide" @default.
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• W1998362112 doi "https://doi.org/10.1136/bjo.2003.021857" @default.
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