Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998377584> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1998377584 endingPage "1349" @default.
- W1998377584 startingPage "1341" @default.
- W1998377584 abstract "The present experiments are an attempt to correlate previously observed decreases in smooth endoplasmic reticulum during malaria infection with changes in drug-metabolizing enzyme activity. Rats were injected with parasitized (P. berghei) red blood cells from donor animals and then sacrificed 1–8 days later. The hepatic microsomal metabolism of ethylmorphine, aniline, p-nitroanisole and hexobarbital showed progressive decreases in rates over the 8-day period. The decreases in metabolism were accompanied by progressive increases in hexobarbital sleeping time. The per cent parasitemia also increased over this period. The presence of a rather severe malarial infection did not prevent the induction of microsomal enzymes by phenobarbital. The reduction in enzyme activity during malarial infection and the increases in activity seen after phenobarbital administration were accompanied by similar alterations in cytochrome P-450 content. Despite the decrease in enzyme activity, microsomal protein content remained essentially unchanged during the first 6 days of the infection. It remains to be determined whether the observed biochemical changes result from a direct action of the parasite or are secondary effects of the infection." @default.
- W1998377584 created "2016-06-24" @default.
- W1998377584 creator A5015865425 @default.
- W1998377584 creator A5044797275 @default.
- W1998377584 creator A5050137062 @default.
- W1998377584 creator A5080103279 @default.
- W1998377584 date "1970-04-01" @default.
- W1998377584 modified "2023-09-25" @default.
- W1998377584 title "Effects of malarial infection on host microsomal drug-metabolizing enzymes" @default.
- W1998377584 cites W1775749144 @default.
- W1998377584 cites W1951469402 @default.
- W1998377584 cites W1976449722 @default.
- W1998377584 cites W2005826953 @default.
- W1998377584 cites W2006960798 @default.
- W1998377584 cites W2026319932 @default.
- W1998377584 cites W2028963902 @default.
- W1998377584 cites W2034834397 @default.
- W1998377584 cites W2057911008 @default.
- W1998377584 cites W2060336079 @default.
- W1998377584 cites W2062649297 @default.
- W1998377584 cites W2064500198 @default.
- W1998377584 cites W2073366141 @default.
- W1998377584 cites W2086307826 @default.
- W1998377584 cites W2095164493 @default.
- W1998377584 cites W4248955078 @default.
- W1998377584 doi "https://doi.org/10.1016/0006-2952(70)90049-3" @default.
- W1998377584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5513924" @default.
- W1998377584 hasPublicationYear "1970" @default.
- W1998377584 type Work @default.
- W1998377584 sameAs 1998377584 @default.
- W1998377584 citedByCount "37" @default.
- W1998377584 countsByYear W19983775842019 @default.
- W1998377584 countsByYear W19983775842021 @default.
- W1998377584 countsByYear W19983775842023 @default.
- W1998377584 crossrefType "journal-article" @default.
- W1998377584 hasAuthorship W1998377584A5015865425 @default.
- W1998377584 hasAuthorship W1998377584A5044797275 @default.
- W1998377584 hasAuthorship W1998377584A5050137062 @default.
- W1998377584 hasAuthorship W1998377584A5080103279 @default.
- W1998377584 hasConcept C126322002 @default.
- W1998377584 hasConcept C134018914 @default.
- W1998377584 hasConcept C181199279 @default.
- W1998377584 hasConcept C185592680 @default.
- W1998377584 hasConcept C203014093 @default.
- W1998377584 hasConcept C2775867548 @default.
- W1998377584 hasConcept C2777237215 @default.
- W1998377584 hasConcept C2777466164 @default.
- W1998377584 hasConcept C2778048844 @default.
- W1998377584 hasConcept C2778371730 @default.
- W1998377584 hasConcept C2778793413 @default.
- W1998377584 hasConcept C2780753045 @default.
- W1998377584 hasConcept C28212737 @default.
- W1998377584 hasConcept C55493867 @default.
- W1998377584 hasConcept C62231903 @default.
- W1998377584 hasConcept C71924100 @default.
- W1998377584 hasConcept C86803240 @default.
- W1998377584 hasConcept C87644729 @default.
- W1998377584 hasConcept C89311334 @default.
- W1998377584 hasConceptScore W1998377584C126322002 @default.
- W1998377584 hasConceptScore W1998377584C134018914 @default.
- W1998377584 hasConceptScore W1998377584C181199279 @default.
- W1998377584 hasConceptScore W1998377584C185592680 @default.
- W1998377584 hasConceptScore W1998377584C203014093 @default.
- W1998377584 hasConceptScore W1998377584C2775867548 @default.
- W1998377584 hasConceptScore W1998377584C2777237215 @default.
- W1998377584 hasConceptScore W1998377584C2777466164 @default.
- W1998377584 hasConceptScore W1998377584C2778048844 @default.
- W1998377584 hasConceptScore W1998377584C2778371730 @default.
- W1998377584 hasConceptScore W1998377584C2778793413 @default.
- W1998377584 hasConceptScore W1998377584C2780753045 @default.
- W1998377584 hasConceptScore W1998377584C28212737 @default.
- W1998377584 hasConceptScore W1998377584C55493867 @default.
- W1998377584 hasConceptScore W1998377584C62231903 @default.
- W1998377584 hasConceptScore W1998377584C71924100 @default.
- W1998377584 hasConceptScore W1998377584C86803240 @default.
- W1998377584 hasConceptScore W1998377584C87644729 @default.
- W1998377584 hasConceptScore W1998377584C89311334 @default.
- W1998377584 hasIssue "4" @default.
- W1998377584 hasLocation W19983775841 @default.
- W1998377584 hasLocation W19983775842 @default.
- W1998377584 hasOpenAccess W1998377584 @default.
- W1998377584 hasPrimaryLocation W19983775841 @default.
- W1998377584 hasRelatedWork W1595530686 @default.
- W1998377584 hasRelatedWork W1933463215 @default.
- W1998377584 hasRelatedWork W1998377584 @default.
- W1998377584 hasRelatedWork W2003523854 @default.
- W1998377584 hasRelatedWork W2030082433 @default.
- W1998377584 hasRelatedWork W2166752565 @default.
- W1998377584 hasRelatedWork W2256836828 @default.
- W1998377584 hasRelatedWork W2281897957 @default.
- W1998377584 hasRelatedWork W2398425207 @default.
- W1998377584 hasRelatedWork W2414027023 @default.
- W1998377584 hasVolume "19" @default.
- W1998377584 isParatext "false" @default.
- W1998377584 isRetracted "false" @default.
- W1998377584 magId "1998377584" @default.
- W1998377584 workType "article" @default.