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- W1998392208 abstract "In primary cultures of neurons from cerebral cortex and striatum, 30 s stimulation with the excitatory amino acid gluatamate elicited a 5 to 9-fold increase in immediate early gene (IEG) mRNAs. Glutamate increased c-fos, c-jun, jun-B, and NGFI-A (zif/268) mRNAs by binding to both α-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) and N-methyl-d-aspartate (NMDA) receptor types, and increased c-fos, jun-B, and NGFI-A mRNAs by binding to the metabotropic receptor. NMDA receptor activation elicited IEG expression by a transmembrane calcium influx: AMPA receptor-induced depolarization played a permissive role for the opening of the NMDA receptor channel. The protein kinase C (PKC) inhibitor H-7 (but not inhibitors of cyclic nucleotide-dependent and calcium/calmodulin-dependent protein kinases) partially blocked IEG expression induced by glutamate." @default.
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- W1998392208 date "1992-01-01" @default.
- W1998392208 modified "2023-09-23" @default.
- W1998392208 title "Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons" @default.
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- W1998392208 doi "https://doi.org/10.1016/0169-328x(92)90089-t" @default.
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