FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998396050> ?p ?o ?g. }

• W1998396050 endingPage "2911" @default.
• W1998396050 startingPage "2900" @default.
• W1998396050 abstract "Transcription factor p53 forms a network with associated factors to regulate the cell cycle and apoptosis in response to environmental stresses. However, there is currently no direct genetic evidence to show if or how the p53 pathway functions during organogenesis. Here we present evidence to show that the zebrafish def (digestive-organ expansion factor) gene encodes a novel pan-endoderm-specific factor. A loss-of-function mutation in def confers hypoplastic digestive organs and selectively up-regulates the expression of Δ 113p53 , counterpart to a newly identified isoform of p53 produced by an alternative internal promoter in intron 4 of the p53 gene in human. The increased Δ 113p53 expression is limited to within the mutant digestive organs, and this increase selectively induces the expression of p53-responsive genes to trigger the arrest of the cell cycle but not apoptosis, resulting in compromised organ growth in the mutant. Our data demonstrate that, while induction of expression of p53 and/or its isoforms is crucial to suppress abnormal cell growth, Δ 113p53 is tightly regulated by an organ/tissue-specific factor Def, especially during organogenesis, to prevent adverse inhibition of organ/tissue growth." @default.
• W1998396050 created "2016-06-24" @default.
• W1998396050 creator A5000328709 @default.
• W1998396050 creator A5017867823 @default.
• W1998396050 creator A5019407635 @default.
• W1998396050 creator A5043387503 @default.
• W1998396050 creator A5057115412 @default.
• W1998396050 creator A5058638624 @default.
• W1998396050 creator A5058822190 @default.
• W1998396050 creator A5061739265 @default.
• W1998396050 creator A5082857859 @default.
• W1998396050 creator A5089210457 @default.
• W1998396050 date "2005-12-01" @default.
• W1998396050 modified "2023-10-01" @default.
• W1998396050 title "Loss of function of <i>def</i> selectively up-regulates Δ<i>113p53</i> expression to arrest expansion growth of digestive organs in zebrafish" @default.
• W1998396050 cites W1483496013 @default.
• W1998396050 cites W1488156534 @default.
• W1998396050 cites W1552426876 @default.
• W1998396050 cites W1650797637 @default.
• W1998396050 cites W1870720170 @default.
• W1998396050 cites W1930957416 @default.
• W1998396050 cites W1964639766 @default.
• W1998396050 cites W1966123083 @default.
• W1998396050 cites W1967284814 @default.
• W1998396050 cites W1969044026 @default.
• W1998396050 cites W1969645108 @default.
• W1998396050 cites W1969871703 @default.
• W1998396050 cites W1975411923 @default.
• W1998396050 cites W1983809853 @default.
• W1998396050 cites W1984755213 @default.
• W1998396050 cites W1988006639 @default.
• W1998396050 cites W1991494214 @default.
• W1998396050 cites W2006435867 @default.
• W1998396050 cites W2018970660 @default.
• W1998396050 cites W2020630430 @default.
• W1998396050 cites W2025757608 @default.
• W1998396050 cites W2034918846 @default.
• W1998396050 cites W2036464863 @default.
• W1998396050 cites W2040131518 @default.
• W1998396050 cites W2043220386 @default.
• W1998396050 cites W2044431281 @default.
• W1998396050 cites W2048663475 @default.
• W1998396050 cites W2049371771 @default.
• W1998396050 cites W2055349083 @default.
• W1998396050 cites W2056079046 @default.
• W1998396050 cites W2064653829 @default.
• W1998396050 cites W2088434258 @default.
• W1998396050 cites W2098597135 @default.
• W1998396050 cites W2099907467 @default.
• W1998396050 cites W2104803182 @default.
• W1998396050 cites W2109991710 @default.
• W1998396050 cites W2114277691 @default.
• W1998396050 cites W2126679757 @default.
• W1998396050 cites W2131989828 @default.
• W1998396050 cites W2136545880 @default.
• W1998396050 cites W2138964504 @default.
• W1998396050 cites W2141735759 @default.
• W1998396050 cites W2142167067 @default.
• W1998396050 cites W2143973293 @default.
• W1998396050 cites W2145116215 @default.
• W1998396050 cites W2146927398 @default.
• W1998396050 cites W2147553368 @default.
• W1998396050 cites W2155570392 @default.
• W1998396050 cites W2159199900 @default.
• W1998396050 cites W2160922979 @default.
• W1998396050 cites W2171317581 @default.
• W1998396050 cites W25031820 @default.
• W1998396050 cites W4231857508 @default.
• W1998396050 cites W4240362136 @default.
• W1998396050 doi "https://doi.org/10.1101/gad.1366405" @default.
• W1998396050 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1315396" @default.
• W1998396050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16322560" @default.
• W1998396050 hasPublicationYear "2005" @default.
• W1998396050 type Work @default.
• W1998396050 sameAs 1998396050 @default.
• W1998396050 citedByCount "158" @default.
• W1998396050 countsByYear W19983960502012 @default.
• W1998396050 countsByYear W19983960502013 @default.
• W1998396050 countsByYear W19983960502014 @default.
• W1998396050 countsByYear W19983960502015 @default.
• W1998396050 countsByYear W19983960502016 @default.
• W1998396050 countsByYear W19983960502017 @default.
• W1998396050 countsByYear W19983960502018 @default.
• W1998396050 countsByYear W19983960502019 @default.
• W1998396050 countsByYear W19983960502020 @default.
• W1998396050 countsByYear W19983960502021 @default.
• W1998396050 countsByYear W19983960502022 @default.
• W1998396050 countsByYear W19983960502023 @default.
• W1998396050 crossrefType "journal-article" @default.
• W1998396050 hasAuthorship W1998396050A5000328709 @default.
• W1998396050 hasAuthorship W1998396050A5017867823 @default.
• W1998396050 hasAuthorship W1998396050A5019407635 @default.
• W1998396050 hasAuthorship W1998396050A5043387503 @default.
• W1998396050 hasAuthorship W1998396050A5057115412 @default.
• W1998396050 hasAuthorship W1998396050A5058638624 @default.
• W1998396050 hasAuthorship W1998396050A5058822190 @default.
• W1998396050 hasAuthorship W1998396050A5061739265 @default.
• W1998396050 hasAuthorship W1998396050A5082857859 @default.

• next