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- W1998400370 abstract "Summary. Activation of the contact system in patients treated with fibrinolytic agents may be an important source of thrombin that activates thrombin-activated fibrinolysis inhibitor (TAFI) and attenuates fibrinolysis. Factor (F)XIIa in plasma increased 2-fold over 60 min in patients given either tissue plasminogen activator (t-PA) or streptokinase (SK). To determine whether FXIIa-mediated generation of thrombin and activated TAFI (TAFIa) attenuates fibrinolysis in vitro, plasma clots were incubated with SK (250 U mL−1) or t-PA (2.5 g mL−1) and the rate of lysis was measured. Plasma FXIIa impaired lysis judging from marked acceleration when 2.5 µm corn trypsin inhibitor were added (lysis increased by 172 ± 144% for SK and 40 ± 31% for t-PA vs. no inhibitor, n = 16, P < 0.01). Moreover, inhibition of thrombin with hirudin and TAFIa with carboxypeptidase inhibitor accelerated lysis. We conclude that activation of FXII increases thrombin generation, which promotes TAFIa-mediated attenuation of fibrinolysis." @default.
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- W1998400370 date "2004-01-01" @default.
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- W1998400370 title "Factor XII‐dependent increases in thrombin activity induce carboxypeptidase‐mediated attenuation of pharmacological fibrinolysis" @default.
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- W1998400370 doi "https://doi.org/10.1111/j.1538-7836.2004.00538.x" @default.
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