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- W1998405475 abstract "In Brief Purpose: To demonstrate that injection of botulinum toxin type A is less painful when mixed with preserved saline compared with the suggested preservative-free saline reconstitution. Methods: Two different injections were compared on 20 patients who had prior botulinum toxin type A treatments. Each side was injected with toxin reconstituted with either preserved or nonpreserved (0.9%) saline. The investigators and patients were blinded, and outcome was assessed with a verbal scale. Clinical outcome was subjectively and informally assessed by patient questioning and physician observation. Results: Injection of botulinum toxin type A was noted to be less painful with the use of the preserved compared with the nonpreserved preparation (P<0.0001). The preserved reconstitution appeared to have no effect on clinical outcome. Conclusions: Injection of botulinum toxin reconstituted with preserved saline is less painful than nonpreserved saline preparations. Treatment of essential blepharospasm with botulinum toxin is significantly less painful with the use of preparations with preserved saline versus nonpreserved saline." @default.
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- W1998405475 date "2004-05-01" @default.
- W1998405475 modified "2023-10-11" @default.
- W1998405475 title "Increased Patient Comfort Utilizing Botulinum Toxin Type A Reconstituted with Preserved Versus Nonpreserved Saline" @default.
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- W1998405475 doi "https://doi.org/10.1097/01.iop.0000129012.09632.49" @default.
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