Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998405912> ?p ?o ?g. }
- W1998405912 endingPage "841" @default.
- W1998405912 startingPage "827" @default.
- W1998405912 abstract "The muscle-specific intermediate filament protein, desmin, is one of the earliest myogenic markers whose functional role during myogenic commitment and differentiation is unknown. Sequence comparison of the presently isolated and fully characterized mouse desmin cDNA clones revealed a single domain of polypeptide similarity between desmin and the basic and helix-loop-helix region of members of the myoD family myogenic regulators. This further substantiated the need to search for the function of desmin. Constructs designed to express anti-sense desmin RNA were used to obtain stably transfected C2C12 myoblast cell lines. Several lines were obtained where expression of the anti-sense desmin RNA inhibited the expression of desmin RNA and protein down to basal levels. As a consequence, the differentiation of these myoblasts was blocked; complete inhibition of myoblast fusion and myotube formation was observed. Rescue of the normal phenotype was achieved either by spontaneous revertants, or by overexpression of the desmin sense RNA in the defective cell lines. In several of the cell lines obtained, inhibition of desmin expression was followed by differential inhibition of the myogenic regulators myoD and/or myogenin, depending on the stage and extent of desmin inhibition in these cells. These data suggested that myogenesis is modulated by at least more than one pathway and desmin, which so far was believed to be merely an architectural protein, seems to play a key role in this process." @default.
- W1998405912 created "2016-06-24" @default.
- W1998405912 creator A5019485507 @default.
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- W1998405912 creator A5065859286 @default.
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- W1998405912 creator A5079587342 @default.
- W1998405912 date "1994-03-01" @default.
- W1998405912 modified "2023-10-08" @default.
- W1998405912 title "Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin" @default.
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