FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998406670> ?p ?o ?g. }

• W1998406670 endingPage "1059" @default.
• W1998406670 startingPage "1050" @default.
• W1998406670 abstract "The purpose of this study was to characterize the retention kinetics of recombinant human bone morphogenetic protein-2 (rhBMP-2) applied to two calcium-based delivery matrices. Biphasic calcium phosphate (BCP) and a composite containing BCP in an absorbable collagen sponge (BCP/ACS) were evaluated using a spinal fusion model in rabbits. rhBMP-2 labeled with radioactive iodine (125I) was used as a tracer to assess in vivo retention of rhBMP-2 in the presence of these materials (nine animals per material studied). Over a 36 day study period, animals were assessed for the following: percent administered dose retained at the implant site as measured by scintigraphic imaging (counting) with a gamma camera (all animals), radiography of the implant site (all animals), radioactivity in blood and plasma (all animals), and radioactivity in the urine and feces (three animals for each material). Radioactivity data were corrected for the decay of 125I and the attenuation between the implant in vivo and the gamma camera. Differences observed between the two materials for the area under the retention vs. time profile (AUC; 988%*day for BCP vs. 1070%*day for BCP/ACS, p = 0.57) and the mean residence time (MRT; 10.2 days for BCP vs. 7.6 days for BCP/ACS, p = 0.06) were not statistically significant. Initial retention/incorporation of rhBMP-2 was slightly higher for rhBMP-2/BCP/ACS than for rhBMP-2/BCP (96.8% vs. 86.0%, p < 0.05). Animals receiving rhBMP-2/BCP showed a longer terminal retention half-life (t1/2) than did those receiving rhBMP-2/BCP/ACS (7.5 vs. 4.5 days, p < 0.05). The urinary radioactivity recovery data supported the data obtained by scintigraphy. Over the 36 day collection period, essentially complete recovery of radioactivity (dose) in urine was observed for rhBMP-2/BCP and rhBMP-2/BCP/ACS and the majority of the radioactivity (approximately 95%) was soluble in trichloroacetic acid, suggesting extensive catabolism of rhBMP-2 before renal excretion. Fecal recovery of radioactivity was low, approximately 2-3%. In conclusion, rhBMP-2 was retained at the implant site when delivered with either BCP or BCP/ACS based on mean residence time and area under the retention curve vs. time profile. Use of these matrices resulted in detectable rhBMP-2 levels at the surgical site for over a week in contrast to data reported with several other matrices that lasted less time. Systemic catabolism and elimination of the rhBMP-2 was extensive and systemic presence of the protein was negligible." @default.
• W1998406670 created "2016-06-24" @default.
• W1998406670 creator A5002847881 @default.
• W1998406670 creator A5002851718 @default.
• W1998406670 creator A5005109753 @default.
• W1998406670 creator A5021520056 @default.
• W1998406670 creator A5040632685 @default.
• W1998406670 creator A5043569181 @default.
• W1998406670 creator A5046033124 @default.
• W1998406670 creator A5056043294 @default.
• W1998406670 creator A5076523333 @default.
• W1998406670 creator A5080993852 @default.
• W1998406670 date "2002-09-01" @default.
• W1998406670 modified "2023-10-07" @default.
• W1998406670 title "Retention of125I-labeled recombinant human bone morphogenetic protein-2 by biphasic calcium phosphate or a composite sponge in a rabbit posterolateral spine arthrodesis model" @default.
• W1998406670 cites W154876906 @default.
• W1998406670 cites W1968609404 @default.
• W1998406670 cites W1969010257 @default.
• W1998406670 cites W1990816910 @default.
• W1998406670 cites W1999702984 @default.
• W1998406670 cites W2014041696 @default.
• W1998406670 cites W2023428546 @default.
• W1998406670 cites W2036997351 @default.
• W1998406670 cites W2042245227 @default.
• W1998406670 cites W2065913782 @default.
• W1998406670 cites W2082003638 @default.
• W1998406670 cites W2094321766 @default.
• W1998406670 cites W2117115638 @default.
• W1998406670 cites W2127109458 @default.
• W1998406670 cites W2131707650 @default.
• W1998406670 cites W2321576862 @default.
• W1998406670 cites W2409446727 @default.
• W1998406670 cites W4239171241 @default.
• W1998406670 cites W4243026607 @default.
• W1998406670 cites W4376848429 @default.
• W1998406670 cites W49726960 @default.
• W1998406670 doi "https://doi.org/10.1016/s0736-0266(02)00011-6" @default.
• W1998406670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12382973" @default.
• W1998406670 hasPublicationYear "2002" @default.
• W1998406670 type Work @default.
• W1998406670 sameAs 1998406670 @default.
• W1998406670 citedByCount "66" @default.
• W1998406670 countsByYear W19984066702012 @default.
• W1998406670 countsByYear W19984066702013 @default.
• W1998406670 countsByYear W19984066702014 @default.
• W1998406670 countsByYear W19984066702015 @default.
• W1998406670 countsByYear W19984066702016 @default.
• W1998406670 countsByYear W19984066702017 @default.
• W1998406670 countsByYear W19984066702018 @default.
• W1998406670 countsByYear W19984066702019 @default.
• W1998406670 countsByYear W19984066702020 @default.
• W1998406670 countsByYear W19984066702021 @default.
• W1998406670 countsByYear W19984066702022 @default.
• W1998406670 crossrefType "journal-article" @default.
• W1998406670 hasAuthorship W1998406670A5002847881 @default.
• W1998406670 hasAuthorship W1998406670A5002851718 @default.
• W1998406670 hasAuthorship W1998406670A5005109753 @default.
• W1998406670 hasAuthorship W1998406670A5021520056 @default.
• W1998406670 hasAuthorship W1998406670A5040632685 @default.
• W1998406670 hasAuthorship W1998406670A5043569181 @default.
• W1998406670 hasAuthorship W1998406670A5046033124 @default.
• W1998406670 hasAuthorship W1998406670A5056043294 @default.
• W1998406670 hasAuthorship W1998406670A5076523333 @default.
• W1998406670 hasAuthorship W1998406670A5080993852 @default.
• W1998406670 hasBestOaLocation W19984066701 @default.
• W1998406670 hasConcept C141071460 @default.
• W1998406670 hasConcept C150903083 @default.
• W1998406670 hasConcept C178790620 @default.
• W1998406670 hasConcept C185592680 @default.
• W1998406670 hasConcept C207001950 @default.
• W1998406670 hasConcept C2778849931 @default.
• W1998406670 hasConcept C2780375110 @default.
• W1998406670 hasConcept C2781411149 @default.
• W1998406670 hasConcept C2989005 @default.
• W1998406670 hasConcept C519063684 @default.
• W1998406670 hasConcept C59822182 @default.
• W1998406670 hasConcept C71924100 @default.
• W1998406670 hasConcept C86803240 @default.
• W1998406670 hasConceptScore W1998406670C141071460 @default.
• W1998406670 hasConceptScore W1998406670C150903083 @default.
• W1998406670 hasConceptScore W1998406670C178790620 @default.
• W1998406670 hasConceptScore W1998406670C185592680 @default.
• W1998406670 hasConceptScore W1998406670C207001950 @default.
• W1998406670 hasConceptScore W1998406670C2778849931 @default.
• W1998406670 hasConceptScore W1998406670C2780375110 @default.
• W1998406670 hasConceptScore W1998406670C2781411149 @default.
• W1998406670 hasConceptScore W1998406670C2989005 @default.
• W1998406670 hasConceptScore W1998406670C519063684 @default.
• W1998406670 hasConceptScore W1998406670C59822182 @default.
• W1998406670 hasConceptScore W1998406670C71924100 @default.
• W1998406670 hasConceptScore W1998406670C86803240 @default.
• W1998406670 hasIssue "5" @default.
• W1998406670 hasLocation W19984066701 @default.
• W1998406670 hasLocation W19984066702 @default.
• W1998406670 hasOpenAccess W1998406670 @default.
• W1998406670 hasPrimaryLocation W19984066701 @default.
• W1998406670 hasRelatedWork W2021188643 @default.
• W1998406670 hasRelatedWork W2087767051 @default.

• next