Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998414141> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1998414141 abstract "Almost 10% of the human genome consists of DNA sequences that share homology with retroviruses. These sequences, which represent a stable component of the human genome (although some may retain the ability to transpose), remain poorly understood. We used degenerate primers specific to the two conserved regions (boxes 4 and 5) of the retroviral pol gene, common to all retroviruses, and PCR-amplified related sequences from individuals representing two distinct populations: Caucasians and Dogrib Indians. The large number of sequences that are reproducibly amplified represent numerous sites of retroviral integration in the human genome. In both populations studied, one of the two primers yielded a polymorphic band, present in ~30% of the samples, that has probably been present in the human genome since before the divergence of the two populations ~10 000 years ago. It was established that this polymorphism was due to priming-site differences and not to deletions. Further, this priming site is duplicated at two genomic sites (representing 341- and 343-bp fragments) with at least two alleles each. Such novel polymorphisms should provide useful markers and permit assessment of evolutionary mechanisms associated with retroviral-related genomic evolution.Key words: Dogrib Indian, evolution, human genome, polymorphism, retrovirus." @default.
- W1998414141 created "2016-06-24" @default.
- W1998414141 creator A5040456340 @default.
- W1998414141 creator A5058153999 @default.
- W1998414141 creator A5067243453 @default.
- W1998414141 creator A5068512163 @default.
- W1998414141 date "1998-10-01" @default.
- W1998414141 modified "2023-10-14" @default.
- W1998414141 title "A single-primer PCR-based retroviral-related DNA polymorphism shared by two distinct human populations" @default.
- W1998414141 cites W1842375801 @default.
- W1998414141 cites W1979204390 @default.
- W1998414141 cites W2008666823 @default.
- W1998414141 cites W2010024525 @default.
- W1998414141 cites W2013644141 @default.
- W1998414141 cites W2013687810 @default.
- W1998414141 cites W2022184660 @default.
- W1998414141 cites W2032423987 @default.
- W1998414141 cites W2037790714 @default.
- W1998414141 cites W2054827403 @default.
- W1998414141 cites W2059415759 @default.
- W1998414141 cites W2084841290 @default.
- W1998414141 cites W2096590590 @default.
- W1998414141 cites W2099848577 @default.
- W1998414141 cites W2113956933 @default.
- W1998414141 cites W2165290518 @default.
- W1998414141 cites W2255642938 @default.
- W1998414141 cites W2398534594 @default.
- W1998414141 doi "https://doi.org/10.1139/g98-072" @default.
- W1998414141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9809437" @default.
- W1998414141 hasPublicationYear "1998" @default.
- W1998414141 type Work @default.
- W1998414141 sameAs 1998414141 @default.
- W1998414141 citedByCount "4" @default.
- W1998414141 crossrefType "journal-article" @default.
- W1998414141 hasAuthorship W1998414141A5040456340 @default.
- W1998414141 hasAuthorship W1998414141A5058153999 @default.
- W1998414141 hasAuthorship W1998414141A5067243453 @default.
- W1998414141 hasAuthorship W1998414141A5068512163 @default.
- W1998414141 hasConcept C104317684 @default.
- W1998414141 hasConcept C141231307 @default.
- W1998414141 hasConcept C156719811 @default.
- W1998414141 hasConcept C174600577 @default.
- W1998414141 hasConcept C17757408 @default.
- W1998414141 hasConcept C197077220 @default.
- W1998414141 hasConcept C2776294106 @default.
- W1998414141 hasConcept C48931128 @default.
- W1998414141 hasConcept C49105822 @default.
- W1998414141 hasConcept C4918238 @default.
- W1998414141 hasConcept C54355233 @default.
- W1998414141 hasConcept C7029365 @default.
- W1998414141 hasConcept C86803240 @default.
- W1998414141 hasConceptScore W1998414141C104317684 @default.
- W1998414141 hasConceptScore W1998414141C141231307 @default.
- W1998414141 hasConceptScore W1998414141C156719811 @default.
- W1998414141 hasConceptScore W1998414141C174600577 @default.
- W1998414141 hasConceptScore W1998414141C17757408 @default.
- W1998414141 hasConceptScore W1998414141C197077220 @default.
- W1998414141 hasConceptScore W1998414141C2776294106 @default.
- W1998414141 hasConceptScore W1998414141C48931128 @default.
- W1998414141 hasConceptScore W1998414141C49105822 @default.
- W1998414141 hasConceptScore W1998414141C4918238 @default.
- W1998414141 hasConceptScore W1998414141C54355233 @default.
- W1998414141 hasConceptScore W1998414141C7029365 @default.
- W1998414141 hasConceptScore W1998414141C86803240 @default.
- W1998414141 hasLocation W19984141411 @default.
- W1998414141 hasLocation W19984141412 @default.
- W1998414141 hasOpenAccess W1998414141 @default.
- W1998414141 hasPrimaryLocation W19984141411 @default.
- W1998414141 hasRelatedWork W1987318978 @default.
- W1998414141 hasRelatedWork W2019469673 @default.
- W1998414141 hasRelatedWork W2054890113 @default.
- W1998414141 hasRelatedWork W2130783114 @default.
- W1998414141 hasRelatedWork W2132125281 @default.
- W1998414141 hasRelatedWork W2146806115 @default.
- W1998414141 hasRelatedWork W2157891416 @default.
- W1998414141 hasRelatedWork W2166535449 @default.
- W1998414141 hasRelatedWork W2787493604 @default.
- W1998414141 hasRelatedWork W2888211726 @default.
- W1998414141 isParatext "false" @default.
- W1998414141 isRetracted "false" @default.
- W1998414141 magId "1998414141" @default.
- W1998414141 workType "article" @default.