FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998415103> ?p ?o ?g. }

• W1998415103 endingPage "2612" @default.
• W1998415103 startingPage "2601" @default.
• W1998415103 abstract "Activation of protein kinase C (PKC) potentiates secretion in Aplysia peptidergic neurons, in part by inducing new sites for peptide release at growth cone terminals. The mechanisms by which ion channels are trafficked to such sites are, however, not well understood. We now show that PKC activation rapidly recruits new Ca V 2 subunits to the plasma membrane, and that recruitment is blocked by latrunculin B, an inhibitor of actin polymerization. In contrast, inhibition of microtubule polymerization selectively prevents the appearance of Ca V 2 subunits only at the distal edge of the growth cone. In resting neurons, Ca V 2-containing organelles reside in the central region of growth cones, but are absent from distal lamellipodia. After activation of PKC, these organelles are transported on microtubules to the lamellipodium. The ability to traffic to the most distal sites of channel insertion inside the lamellipodium does, therefore, not require intact actin but requires intact microtubules. Only after activation of PKC do Ca V 2 channels associate with actin and undergo insertion into the plasma membrane." @default.
• W1998415103 created "2016-06-24" @default.
• W1998415103 creator A5009025335 @default.
• W1998415103 creator A5026735042 @default.
• W1998415103 creator A5036389887 @default.
• W1998415103 creator A5060297696 @default.
• W1998415103 creator A5072411299 @default.
• W1998415103 creator A5075701359 @default.
• W1998415103 date "2008-03-05" @default.
• W1998415103 modified "2023-10-16" @default.
• W1998415103 title "PKC-Induced Intracellular Trafficking of Ca_V2 Precedes Its Rapid Recruitment to the Plasma Membrane" @default.
• W1998415103 cites W1498142612 @default.
• W1998415103 cites W1510499710 @default.
• W1998415103 cites W1539774304 @default.
• W1998415103 cites W1545247886 @default.
• W1998415103 cites W1680742557 @default.
• W1998415103 cites W1819068535 @default.
• W1998415103 cites W1859823396 @default.
• W1998415103 cites W1946234283 @default.
• W1998415103 cites W1971704479 @default.
• W1998415103 cites W1974482994 @default.
• W1998415103 cites W1975852922 @default.
• W1998415103 cites W1979625216 @default.
• W1998415103 cites W1983185734 @default.
• W1998415103 cites W1987340259 @default.
• W1998415103 cites W1990076835 @default.
• W1998415103 cites W1998894167 @default.
• W1998415103 cites W1999724177 @default.
• W1998415103 cites W2007915830 @default.
• W1998415103 cites W2010005988 @default.
• W1998415103 cites W2010842131 @default.
• W1998415103 cites W2011292487 @default.
• W1998415103 cites W2011522945 @default.
• W1998415103 cites W2016979915 @default.
• W1998415103 cites W2018752391 @default.
• W1998415103 cites W2024611380 @default.
• W1998415103 cites W2026455360 @default.
• W1998415103 cites W2028156214 @default.
• W1998415103 cites W2033691305 @default.
• W1998415103 cites W2039639156 @default.
• W1998415103 cites W2042733728 @default.
• W1998415103 cites W2043966795 @default.
• W1998415103 cites W2044919076 @default.
• W1998415103 cites W2045441572 @default.
• W1998415103 cites W2047167078 @default.
• W1998415103 cites W2053978255 @default.
• W1998415103 cites W2057912551 @default.
• W1998415103 cites W2060428141 @default.
• W1998415103 cites W2064226680 @default.
• W1998415103 cites W2067890991 @default.
• W1998415103 cites W2079864604 @default.
• W1998415103 cites W2082910935 @default.
• W1998415103 cites W2084904550 @default.
• W1998415103 cites W2087474624 @default.
• W1998415103 cites W2088760800 @default.
• W1998415103 cites W2089017599 @default.
• W1998415103 cites W2089635824 @default.
• W1998415103 cites W2090176996 @default.
• W1998415103 cites W2095099413 @default.
• W1998415103 cites W2101416170 @default.
• W1998415103 cites W2102330287 @default.
• W1998415103 cites W2105630800 @default.
• W1998415103 cites W2106013763 @default.
• W1998415103 cites W2107406042 @default.
• W1998415103 cites W2110060263 @default.
• W1998415103 cites W2119632652 @default.
• W1998415103 cites W2119812460 @default.
• W1998415103 cites W2127124583 @default.
• W1998415103 cites W2127985487 @default.
• W1998415103 cites W2135389965 @default.
• W1998415103 cites W2139574564 @default.
• W1998415103 cites W2146960955 @default.
• W1998415103 cites W2163482001 @default.
• W1998415103 cites W2170603233 @default.
• W1998415103 cites W2170723783 @default.
• W1998415103 cites W2182160837 @default.
• W1998415103 cites W2399871001 @default.
• W1998415103 cites W2417181054 @default.
• W1998415103 cites W4231413660 @default.
• W1998415103 cites W4234925779 @default.
• W1998415103 cites W4297627439 @default.
• W1998415103 doi "https://doi.org/10.1523/jneurosci.4314-07" @default.
• W1998415103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2830008" @default.
• W1998415103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18322103" @default.
• W1998415103 hasPublicationYear "2008" @default.
• W1998415103 type Work @default.
• W1998415103 sameAs 1998415103 @default.
• W1998415103 citedByCount "35" @default.
• W1998415103 countsByYear W19984151032012 @default.
• W1998415103 countsByYear W19984151032013 @default.
• W1998415103 countsByYear W19984151032014 @default.
• W1998415103 countsByYear W19984151032015 @default.
• W1998415103 countsByYear W19984151032016 @default.
• W1998415103 countsByYear W19984151032017 @default.
• W1998415103 countsByYear W19984151032018 @default.
• W1998415103 countsByYear W19984151032019 @default.
• W1998415103 countsByYear W19984151032020 @default.
• W1998415103 countsByYear W19984151032023 @default.

• next