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- W199842010 abstract "4665 Background: IL-8 has been reported to promote CRPC growth [Am J Path1999;1503]. Further, MCP-1 mediates tumor- induced osteoclastogenesis and bone resorption [Cancer Res 2007;3646]. Dasatinib (DAS), a potent SRC-family kinase inhibitor, affects tumor growth and bone turnover induced by CRPC, the latter, by potentially blocking osteoclast activation Thus, the effects of DAS in CRPC might in part be mediated through reduction of either IL-8 and/or MCP-1 levels. Here, we analyzed the correlation between serum peak DAS levels with IL-8 and MCP-1 levels in the phase II portion of a phase I/II study of DAS and docetaxel (D) for treatment of metastatic CRPC. Data was analyzed for patients enrolled at M. D. Anderson Cancer Center (MDACC). Methods: Male pts with progressive CRPC and testosterone levels ≤50 ng/dL requiring chemotherapy were enrolled. Escalating doses of DAS and D were evaluated. The doses selected for the included pts was DAS 100mg QD and D 75mg/m2 Q21D. DAS, IL-8 and MCP-1 levels were measure..." @default.
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- W199842010 date "2010-05-20" @default.
- W199842010 modified "2023-09-26" @default.
- W199842010 title "Correlation of dasatinib (DAS) peak levels with interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) levels in patients with castration-resistant progressive prostate cancer (CRPC)." @default.
- W199842010 doi "https://doi.org/10.1200/jco.2010.28.15_suppl.4665" @default.
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