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• W1998425275 abstract "In Brief Study Design. Retrospective case series. Objective. To evaluate the risk of infection, related treatment, and outcome after surgery of the 2 most common primary sacral tumors. Summary of Background Data. Rarity of sacral tumors has limited the number of population-based studies. Treatment depends on malignancy or local aggressiveness: wide resection is indicated for malignant lesions, intralesional surgery for benign. Methods. We studied 82 patients with sacral chordomas (55 cases) or giant cell tumor (GCT) (27 cases) treated between 1976 and 2005. All patients had IV antibiotic therapy with amikacin and teicoplanin. Surgery of chordoma was resection; surgery of GCT was intralesional excision. Infections were classified as immediate postoperative, early (within 6 months), and late (more than 6 months from surgery). Mean follow-up was 9.5 years (range: 3–27 years). Some factors possibly influencing the risk of infection were statistically analyzed by Kaplan Meier curves and log-rank test. Results. No deep infections were observed in the GCT series. Three patients with sacral chordoma died for postoperative complications and were excluded from this analysis. Of the remaining 52 patients with chordoma, 23/52 had deep wound infection (44%) that required 1 or more surgical debridements combined with antibiotics, according to cultures. In 16 patients (70%), infection occurred within 4 weeks postoperatively, and in 7 within 6 months. Most frequent bacteria were Enterococcus (23%), Escherichia coli (20%), and Pseudomonas aeruginosa (18%). In 74% of cases, infection was multimicrobial. Level of resection, previous intralesional treatment elsewhere, tumor volume, and age did not statistically influence risk of infection. Conclusion. Type of surgery was the prominent factor related to a major risk of infection. Operating procedure time correlated as well. Resections of sacral chordoma imply a high risk of deep infection, while intralesional excision of GCT does not. All infections healed with surgical debridements and antibiotic therapy. This focused review of the literature summarizes cervical spine anomalies found in genetic syndromes. A comprehensive table of syndromes with their respective cervical spine abnormalities is included. Ten syndromes are summarized as examples of the varied causes of upper cervical instability, cervical kyphosis, and global cervical spine involvement." @default.
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• W1998425275 date "2012-03-01" @default.
• W1998425275 modified "2023-10-12" @default.
• W1998425275 title "Infections in Surgery of Primary Tumors of the Sacrum" @default.
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• W1998425275 doi "https://doi.org/10.1097/brs.0b013e3182213a44" @default.
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