Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998430056> ?p ?o ?g. }
- W1998430056 endingPage "349" @default.
- W1998430056 startingPage "341" @default.
- W1998430056 abstract "Testicular germ cell tumors (TGCT) represent the most common malignancy among young males. To our knowledge no comprehensive Copy Number Variation (CNVs) studies of TGCT using high-resolution Single Nucleotide Polymorphism (SNP) array have been performed. By a genome-wide analysis of CNV and loss of heterozygosity (LOH) in 25 primary seminomas, we confirmed several previously reported genomic alterations and discovered eight novel genomic alterations including amplifications and homozygous deletions. Moreover, a comparison of genomic alterations of early and late stage seminoma identified CNVs that correlate with progression, which included deletions in chromosomes 4q, 5p, 9q, 13q and 20p and amplifications in chromosomes 9q and 13q. We compared previously perform Affymetrix expression analysis in a subset of samples and found robust correlation between expression and genomic alterations. Furthermore, high correlations (40-75%) were observed between CNV by SNP analysis and quantitative PCR. Our findings may lead to better understanding of TGTC's pathogenesis." @default.
- W1998430056 created "2016-06-24" @default.
- W1998430056 creator A5001406528 @default.
- W1998430056 creator A5003038217 @default.
- W1998430056 creator A5014887167 @default.
- W1998430056 creator A5019366387 @default.
- W1998430056 creator A5048533064 @default.
- W1998430056 creator A5064618296 @default.
- W1998430056 creator A5071922535 @default.
- W1998430056 creator A5077748897 @default.
- W1998430056 creator A5089555884 @default.
- W1998430056 date "2011-06-01" @default.
- W1998430056 modified "2023-09-27" @default.
- W1998430056 title "Genome-wide analysis of genetic alterations in testicular primary seminoma using high resolution single nucleotide polymorphism arrays" @default.
- W1998430056 cites W1965955251 @default.
- W1998430056 cites W1984825396 @default.
- W1998430056 cites W1991253843 @default.
- W1998430056 cites W1995092994 @default.
- W1998430056 cites W2003903245 @default.
- W1998430056 cites W2013892055 @default.
- W1998430056 cites W2016349702 @default.
- W1998430056 cites W2026084160 @default.
- W1998430056 cites W2031656696 @default.
- W1998430056 cites W2037525721 @default.
- W1998430056 cites W2038331484 @default.
- W1998430056 cites W2041354124 @default.
- W1998430056 cites W2042960439 @default.
- W1998430056 cites W2045012271 @default.
- W1998430056 cites W2046041649 @default.
- W1998430056 cites W2046526373 @default.
- W1998430056 cites W2047855715 @default.
- W1998430056 cites W2049105176 @default.
- W1998430056 cites W2049160829 @default.
- W1998430056 cites W2050688594 @default.
- W1998430056 cites W2054744711 @default.
- W1998430056 cites W2058769734 @default.
- W1998430056 cites W2060853538 @default.
- W1998430056 cites W2063907721 @default.
- W1998430056 cites W2068992831 @default.
- W1998430056 cites W2069933190 @default.
- W1998430056 cites W2070807361 @default.
- W1998430056 cites W2071641249 @default.
- W1998430056 cites W2073225422 @default.
- W1998430056 cites W2074751190 @default.
- W1998430056 cites W2087435869 @default.
- W1998430056 cites W2089473025 @default.
- W1998430056 cites W2089934507 @default.
- W1998430056 cites W2091991690 @default.
- W1998430056 cites W2096299951 @default.
- W1998430056 cites W2099255502 @default.
- W1998430056 cites W2103831849 @default.
- W1998430056 cites W2109062537 @default.
- W1998430056 cites W2109812193 @default.
- W1998430056 cites W2113249561 @default.
- W1998430056 cites W2118836034 @default.
- W1998430056 cites W2119063029 @default.
- W1998430056 cites W2122676947 @default.
- W1998430056 cites W2122885616 @default.
- W1998430056 cites W2128502368 @default.
- W1998430056 cites W2135254067 @default.
- W1998430056 cites W2137819560 @default.
- W1998430056 cites W2146308072 @default.
- W1998430056 cites W2149681218 @default.
- W1998430056 cites W2150823666 @default.
- W1998430056 cites W2152056608 @default.
- W1998430056 cites W2163305167 @default.
- W1998430056 cites W4230482292 @default.
- W1998430056 cites W4242349342 @default.
- W1998430056 doi "https://doi.org/10.1016/j.ygeno.2011.02.011" @default.
- W1998430056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21376111" @default.
- W1998430056 hasPublicationYear "2011" @default.
- W1998430056 type Work @default.
- W1998430056 sameAs 1998430056 @default.
- W1998430056 citedByCount "25" @default.
- W1998430056 countsByYear W19984300562012 @default.
- W1998430056 countsByYear W19984300562013 @default.
- W1998430056 countsByYear W19984300562014 @default.
- W1998430056 countsByYear W19984300562015 @default.
- W1998430056 countsByYear W19984300562016 @default.
- W1998430056 countsByYear W19984300562019 @default.
- W1998430056 countsByYear W19984300562020 @default.
- W1998430056 countsByYear W19984300562021 @default.
- W1998430056 countsByYear W19984300562023 @default.
- W1998430056 crossrefType "journal-article" @default.
- W1998430056 hasAuthorship W1998430056A5001406528 @default.
- W1998430056 hasAuthorship W1998430056A5003038217 @default.
- W1998430056 hasAuthorship W1998430056A5014887167 @default.
- W1998430056 hasAuthorship W1998430056A5019366387 @default.
- W1998430056 hasAuthorship W1998430056A5048533064 @default.
- W1998430056 hasAuthorship W1998430056A5064618296 @default.
- W1998430056 hasAuthorship W1998430056A5071922535 @default.
- W1998430056 hasAuthorship W1998430056A5077748897 @default.
- W1998430056 hasAuthorship W1998430056A5089555884 @default.
- W1998430056 hasConcept C104317684 @default.
- W1998430056 hasConcept C120821319 @default.
- W1998430056 hasConcept C122060243 @default.
- W1998430056 hasConcept C135763542 @default.
- W1998430056 hasConcept C139275648 @default.