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• W1998434414 abstract "Department of Cardiovascular & Renal Medicine, Saga University Faculty of Medicine, Saga, Japan Periodontitis is a chronic inflammatory disease associated with degradation of periodontal tissues and ishighly prevalent in late middle age. Statins, such as simvastatin, are pharmacologic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) re-ductase inhibitors that inhibit cholesterol synthesis, which is important in development of arteriosclerosis.Many cardiovascular studies have suggested that statins also have anti-inflammatory effects which areindependent of cholesterol lowering. As a chronic inflammatory disease, periodontitis shares some mecha-nisms with atherosclerosis. Since oral epithelial cells are implicated in periodontal inflammation, we mea-sured simvastatin effects on cytokine [interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12p70, and tumor necrosisfactor α (TNFα)] production by cultured human epithelioid cell line KB cells in response to IL-1 α. Simvastatindecreased production, an effect reversed by adding mevalonate or geranylgeranyl pyrophosphate (GGPP),but not farnesyl pyrophosphate (FPP). Simvastatin was found to reduce NF-κB and AP-1 promoter activityin KB cells. Our results support an anti-inflammatory effect of simvastatin on human oral epithelial cells.Rec.9/29/2006, Acc.12/7/2006, pp107-111" @default.
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• W1998434414 date "2007-01-01" @default.
• W1998434414 modified "2023-10-18" @default.
• W1998434414 title "Anti-inflammatory Effects of Simvastatin on Human Oral Cells" @default.
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• W1998434414 doi "https://doi.org/10.2492/inflammregen.27.107" @default.
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