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• W1998446009 endingPage "20466" @default.
• W1998446009 startingPage "20461" @default.
• W1998446009 abstract "Significance The ability of multicellular organisms to detect and respond to infection by microorganisms is fundamental and has ancient evolutionary origins. In mammals, immune system cells recognize danger molecules directly using “pattern recognition” receptors belonging to the Toll family among others. In insects, by contrast, Gram-positive bacteria and fungi can also be detected indirectly by an endogenous molecule, Spätzle (Spz), that activates related Toll receptors, leading to an effective immune response. In this study, we report the molecular structure of Spz/Toll complex, which reveals that Spz’s mode of action is similar to neurotrophins, a family of proteins involved in the development and homeostasis of the insect and vertebrate nervous systems." @default.
• W1998446009 created "2016-06-24" @default.
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• W1998446009 date "2013-11-26" @default.
• W1998446009 modified "2023-10-10" @default.
• W1998446009 title "Cytokine Spätzle binds to the <i>Drosophila</i> immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation" @default.
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• W1998446009 doi "https://doi.org/10.1073/pnas.1317002110" @default.
• W1998446009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3870763" @default.
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