Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998449095> ?p ?o ?g. }
- W1998449095 endingPage "305" @default.
- W1998449095 startingPage "305" @default.
- W1998449095 abstract "Preparation, in vitro and in vivo evaluation of polymeric nanoparticles based on hyaluronic acid-poly(butyl cyanoacrylate) and D-alpha-tocopheryl polyethylene glycol 1000 succinate for tumor-targeted delivery of morin hydrate Sarra Abbad,1,2 Cheng Wang,1 Ayman Yahia Waddad,1 Huixia Lv,1 Jianping Zhou11Department of Pharmaceutics, China Pharmaceutical University, Nanjing, People’s Republic of China; 2Department of Pharmacy, Abou Bekr Belkaid University, Tlemcen, AlgeriaAbstract: Herein, we describe the preparation of a targeted cellular delivery system for morin hydrate (MH), based on a low-molecular-weight hyaluronic acid-poly(butyl cyanoacrylate) (HA-PBCA) block copolymer. In order to enhance the therapeutic effect of MH, D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) was mixed with HA-PBCA during the preparation process. The MH-loaded HA-PBCA “plain” nanoparticle (MH-PNs) and HA-PBCA/TPGS “mixed” nanoparticles (MH-MNs) were concomitantly characterized in terms of loading efficiency, particle size, zeta potential, critical aggregation concentration, and morphology. The obtained MH-PNs and MH-MNs exhibited a spherical morphology with a negative zeta potential and a particle size less than 200 nm, favorable for drug targeting. Remarkably, the addition of TPGS resulted in about 1.6-fold increase in drug-loading. The in vitro cell viability experiment revealed that MH-MNs enhanced the cytotoxicity of MH in A549 cells compared with MH solution and MH-PNs. Furthermore, blank MNs containing TPGS exhibited selective cytotoxic effects against cancer cells without diminishing the viability of normal cells. In addition, the cellular uptake study indicated that MNs resulted in 2.28-fold higher cellular uptake than that of PNs, in A549 cells. The CD44 receptor competitive inhibition and the internalization pathway studies suggested that the internalization mechanism of the nanoparticles was mediated mainly by the CD44 receptors through a clathrin-dependent endocytic pathway. More importantly, MH-MNs exhibited a higher in vivo antitumor potency and induced more tumor cell apoptosis than did MH-PNs, following intravenous administration to S180 tumor-bearing mice. Overall, the results imply that the developed nanoparticles are promising vehicles for the targeted delivery of lipophilic anticancer drugs.Keywords: anti-tumor effect, hyaluronic acid, TPGS, morin hydrate, nanoparticles" @default.
- W1998449095 created "2016-06-24" @default.
- W1998449095 creator A5017219900 @default.
- W1998449095 creator A5036143549 @default.
- W1998449095 creator A5047134849 @default.
- W1998449095 creator A5054498980 @default.
- W1998449095 creator A5065007862 @default.
- W1998449095 date "2015-01-01" @default.
- W1998449095 modified "2023-09-25" @default.
- W1998449095 title "Preparation, in vitro and in vivo evaluation of polymeric nanoparticles based on hyaluronic acid-poly(butyl cyanoacrylate) and D-alpha-tocopheryl polyethylene glycol 1000 succinate for tumor-targeted delivery of morin hydrate" @default.
- W1998449095 cites W1319875 @default.
- W1998449095 cites W133997253 @default.
- W1998449095 cites W1535472961 @default.
- W1998449095 cites W1573333099 @default.
- W1998449095 cites W1574141446 @default.
- W1998449095 cites W1964180981 @default.
- W1998449095 cites W1964847440 @default.
- W1998449095 cites W1970786982 @default.
- W1998449095 cites W1974373425 @default.
- W1998449095 cites W1976073542 @default.
- W1998449095 cites W1977819870 @default.
- W1998449095 cites W1980884243 @default.
- W1998449095 cites W1986898135 @default.
- W1998449095 cites W1987151994 @default.
- W1998449095 cites W1987625413 @default.
- W1998449095 cites W1988400258 @default.
- W1998449095 cites W1992070884 @default.
- W1998449095 cites W1997723307 @default.
- W1998449095 cites W1999327728 @default.
- W1998449095 cites W2002849965 @default.
- W1998449095 cites W2004680537 @default.
- W1998449095 cites W2004698198 @default.
- W1998449095 cites W2016097990 @default.
- W1998449095 cites W2017201573 @default.
- W1998449095 cites W2017449981 @default.
- W1998449095 cites W2024236133 @default.
- W1998449095 cites W2026465049 @default.
- W1998449095 cites W2034887257 @default.
- W1998449095 cites W2037653676 @default.
- W1998449095 cites W2038626534 @default.
- W1998449095 cites W2040067584 @default.
- W1998449095 cites W2044240043 @default.
- W1998449095 cites W2053116571 @default.
- W1998449095 cites W2054095401 @default.
- W1998449095 cites W2054757669 @default.
- W1998449095 cites W2058280602 @default.
- W1998449095 cites W2059890286 @default.
- W1998449095 cites W2060265857 @default.
- W1998449095 cites W2067291446 @default.
- W1998449095 cites W2069356522 @default.
- W1998449095 cites W2069424265 @default.
- W1998449095 cites W2073061907 @default.
- W1998449095 cites W2073234977 @default.
- W1998449095 cites W2074905314 @default.
- W1998449095 cites W2086833548 @default.
- W1998449095 cites W2090854525 @default.
- W1998449095 cites W2091390963 @default.
- W1998449095 cites W2091672301 @default.
- W1998449095 cites W2092676645 @default.
- W1998449095 cites W2092721610 @default.
- W1998449095 cites W2093188120 @default.
- W1998449095 cites W2102941764 @default.
- W1998449095 cites W2118071096 @default.
- W1998449095 cites W2125187315 @default.
- W1998449095 cites W2135794418 @default.
- W1998449095 cites W2148883919 @default.
- W1998449095 cites W2153691074 @default.
- W1998449095 cites W2154335294 @default.
- W1998449095 cites W2157175890 @default.
- W1998449095 cites W2157274368 @default.
- W1998449095 cites W2157428889 @default.
- W1998449095 cites W2163592912 @default.
- W1998449095 cites W2169678660 @default.
- W1998449095 cites W2171220219 @default.
- W1998449095 cites W2172260616 @default.
- W1998449095 cites W2185193730 @default.
- W1998449095 doi "https://doi.org/10.2147/ijn.s73971" @default.
- W1998449095 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4293365" @default.
- W1998449095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25609946" @default.
- W1998449095 hasPublicationYear "2015" @default.
- W1998449095 type Work @default.
- W1998449095 sameAs 1998449095 @default.
- W1998449095 citedByCount "20" @default.
- W1998449095 countsByYear W19984490952015 @default.
- W1998449095 countsByYear W19984490952016 @default.
- W1998449095 countsByYear W19984490952017 @default.
- W1998449095 countsByYear W19984490952018 @default.
- W1998449095 countsByYear W19984490952019 @default.
- W1998449095 countsByYear W19984490952020 @default.
- W1998449095 countsByYear W19984490952021 @default.
- W1998449095 countsByYear W19984490952022 @default.
- W1998449095 countsByYear W19984490952023 @default.
- W1998449095 crossrefType "journal-article" @default.
- W1998449095 hasAuthorship W1998449095A5017219900 @default.
- W1998449095 hasAuthorship W1998449095A5036143549 @default.
- W1998449095 hasAuthorship W1998449095A5047134849 @default.
- W1998449095 hasAuthorship W1998449095A5054498980 @default.
- W1998449095 hasAuthorship W1998449095A5065007862 @default.