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- W1998459062 abstract "Despite high expression levels at the plasma membrane or in intracellular vesicles, tetraspanins remain among the most mysterious transmembrane molecules 20 years after their discovery. Several genetic studies in mammals and invertebrates have demonstrated key physiological roles for some of these tetraspanins, in particular in the immune response, sperm–egg fusion, photoreceptor function and the normal function of certain epithelia. Other studies have highlighted their ability to modulate cell migration and metastasis formation. Their role in the propagation of infectious agents has drawn recent attention, with evidence for HIV budding in tetraspanin-enriched plasma membrane domains. Infection of hepatocytic cells by two major pathogens, the hepatitis C virus and the malaria parasite, also requires the tetraspanin CD81. The function of tetraspanins is thought to be linked to their ability to associate with one another and a wealth of other integral proteins, thereby building up an interacting network or ‘tetraspanin web’. On the basis of the biochemical dissection of the tetraspanin web and recent analysis of the dynamics of some of its constituents, we propose that tetraspanins tightly regulate transient interactions between a variety of molecules and as such favour the efficient assembly of specialized structures upon proper stimulation." @default.
- W1998459062 created "2016-06-24" @default.
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- W1998459062 date "2009-05-13" @default.
- W1998459062 modified "2023-10-05" @default.
- W1998459062 title "Lateral organization of membrane proteins: tetraspanins spin their web" @default.
- W1998459062 cites W1514708207 @default.
- W1998459062 cites W1515952044 @default.
- W1998459062 cites W1520425169 @default.
- W1998459062 cites W1525967044 @default.
- W1998459062 cites W1536183222 @default.
- W1998459062 cites W1546944826 @default.
- W1998459062 cites W1551883442 @default.
- W1998459062 cites W1564861448 @default.
- W1998459062 cites W1565219603 @default.
- W1998459062 cites W156564485 @default.
- W1998459062 cites W1576773659 @default.
- W1998459062 cites W1611220303 @default.
- W1998459062 cites W1620395613 @default.
- W1998459062 cites W1665767818 @default.
- W1998459062 cites W1675877390 @default.
- W1998459062 cites W1831764476 @default.
- W1998459062 cites W1908004582 @default.
- W1998459062 cites W1929719444 @default.
- W1998459062 cites W1930568966 @default.
- W1998459062 cites W1963509770 @default.
- W1998459062 cites W1964233209 @default.
- W1998459062 cites W1966014033 @default.
- W1998459062 cites W1966790817 @default.
- W1998459062 cites W1967946955 @default.
- W1998459062 cites W1968166269 @default.
- W1998459062 cites W1968807810 @default.
- W1998459062 cites W1969694448 @default.
- W1998459062 cites W1970651122 @default.
- W1998459062 cites W1970858060 @default.
- W1998459062 cites W1975898667 @default.
- W1998459062 cites W1975959933 @default.
- W1998459062 cites W1977036616 @default.
- W1998459062 cites W1977947175 @default.
- W1998459062 cites W1978781892 @default.
- W1998459062 cites W1979586234 @default.
- W1998459062 cites W1979738242 @default.
- W1998459062 cites W1981715542 @default.
- W1998459062 cites W1981862901 @default.
- W1998459062 cites W1984109999 @default.
- W1998459062 cites W1984889375 @default.
- W1998459062 cites W1985187521 @default.
- W1998459062 cites W1986218383 @default.
- W1998459062 cites W1991923672 @default.
- W1998459062 cites W1992660677 @default.
- W1998459062 cites W1992837561 @default.
- W1998459062 cites W1994673736 @default.
- W1998459062 cites W1994928799 @default.
- W1998459062 cites W1996338382 @default.
- W1998459062 cites W1996764186 @default.
- W1998459062 cites W1996982253 @default.
- W1998459062 cites W1998761187 @default.
- W1998459062 cites W1999937407 @default.
- W1998459062 cites W1999977344 @default.
- W1998459062 cites W2000401606 @default.
- W1998459062 cites W2001212328 @default.
- W1998459062 cites W2003072982 @default.
- W1998459062 cites W2003549561 @default.
- W1998459062 cites W2008133764 @default.
- W1998459062 cites W2008442497 @default.
- W1998459062 cites W2011025186 @default.
- W1998459062 cites W2011189175 @default.
- W1998459062 cites W2011745672 @default.
- W1998459062 cites W2012289375 @default.
- W1998459062 cites W2013289215 @default.
- W1998459062 cites W2014115532 @default.
- W1998459062 cites W2015928161 @default.
- W1998459062 cites W2018042005 @default.
- W1998459062 cites W2018842010 @default.
- W1998459062 cites W2019126794 @default.
- W1998459062 cites W2019815668 @default.
- W1998459062 cites W2020691341 @default.
- W1998459062 cites W2020859067 @default.
- W1998459062 cites W2022685199 @default.
- W1998459062 cites W2023036916 @default.
- W1998459062 cites W2023165881 @default.
- W1998459062 cites W2025683762 @default.
- W1998459062 cites W2026700392 @default.
- W1998459062 cites W2027345133 @default.
- W1998459062 cites W2027509786 @default.
- W1998459062 cites W2027802778 @default.
- W1998459062 cites W2027816144 @default.
- W1998459062 cites W2028504554 @default.
- W1998459062 cites W2028540820 @default.
- W1998459062 cites W2031392025 @default.
- W1998459062 cites W2033193989 @default.
- W1998459062 cites W2033519215 @default.
- W1998459062 cites W2033867518 @default.