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- W1998464377 abstract "We analyzed lipids from leukemic cells of two patients with adult T-cell leukemia and compared them with those from T-cell lymphocytes of normal subjects. The neutral glycosphingolipids and gangliosides which were isolated were characterized by thin-layer chromatography and neuraminidase treatment. Both leukemic cells and normal lymphocytes had monoglycosylceramide and diglycosylceramide as major neutral glycosphingolipids. In one patient, diglycosylceramide was markedly increased. II3NeuAc-LacCer (GM3) and more complex gangliosides were detected in both cells. The most characteristic finding in leukemic cells was the occurrence of a disialylated ganglioside, II3(NeuAc)2-LacCer (GD3), which is not found in normal lymphocytes and neutrophils. This ganglioside may be due to the induced synthesis in association with malignant transformation." @default.
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- W1998464377 date "1985-05-01" @default.
- W1998464377 modified "2023-09-24" @default.
- W1998464377 title "Glycosphingolipids of leukemic cells in adult T-cell leukemia-lymphoma" @default.
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- W1998464377 doi "https://doi.org/10.1016/0005-2760(85)90013-x" @default.
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