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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998464897> ?p ?o ?g. }

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• W1998464897 abstract "This randomised clinical trial, involving patients with advanced colorectal cancer, was carried out to compare the effectiveness of accelerated folinic acid (FA) plus 5-fluorouracil (5-FU) with that of the conventional regimen of 5-FU alone. Both regimens were administered with simultaneous supportive care. 185 patients were eligible: 94 were randomly allocated to receive FA 200 mg/m2 i.v. plus 5-FU 400 mg/m2 i.v. on days 1–5 every 3 weeks; and 91 to receive 5-FU 400 mg/m2 i.v. on days 1–5 every 4 weeks. The response rate was 33.3% in the accelerated FA/ 5-FU and 18.6% in the 5-FU arm (P = 0.045). Median survival was 13.5 months in the FA/5-FU arm and 7.5 months in the 5-FU arm (P = 0.039). Toxicity was mild and slightly more pronounced in the FA/5-FU arm (P = 0.078). This study indicates that, in patients with advanced colorectal cancer, accelerated chemotherapy with FA and 5-FU and simultaneous supportive care is capable of achieving a higher response rate and longer survival than conventional 5-FU alone, without severe toxicity." @default.
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• W1998464897 date "1995-11-01" @default.
• W1998464897 modified "2023-09-23" @default.
• W1998464897 title "Treatment of advanced colorectal cancer with high-dose intensity folinic acid and 5-fluorouracil plus supportive care" @default.
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• W1998464897 doi "https://doi.org/10.1016/0959-8049(95)00488-2" @default.
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