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• W1998508434 abstract "Predicting the binding specificity of transcription factors is a critical step in the characterization and computational identification and of cis-regulatory elements in genomic sequences. Here we use protein–DNA structures to predict binding specificity and consider the possibility of predicting position weight matrices (PWM) for an entire protein family based on the structures of just a few family members. A particular focus is the sensitivity of prediction accuracy to the docking geometry of the structure used. We investigate this issue with the goal of determining how similar two docking geometries must be for binding specificity predictions to be accurate. Docking similarity is quantified using our recently described interface alignment score (IAS). Using a molecular-mechanics force field, we predict high-affinity nucleotide sequences that bind to the second zinc-finger (ZF) domain from the Zif268 protein, using different C2H2 ZF domains as structural templates. We identify a strong relationship between IAS values and prediction accuracy, and define a range of IAS values for which accurate structure-based predictions of binding specificity is to be expected. The implication of our results for large-scale, structure-based prediction of PWMs is discussed." @default.
• W1998508434 created "2016-06-24" @default.
• W1998508434 creator A5036654109 @default.
• W1998508434 creator A5073024394 @default.
• W1998508434 date "2007-01-30" @default.
• W1998508434 modified "2023-09-26" @default.
• W1998508434 title "Structure-based prediction of C2H2 zinc-finger binding specificity: sensitivity to docking geometry" @default.
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• W1998508434 doi "https://doi.org/10.1093/nar/gkl1155" @default.
• W1998508434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1851644" @default.
• W1998508434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17264128" @default.
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