Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998511394> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1998511394 endingPage "239" @default.
- W1998511394 startingPage "232" @default.
- W1998511394 abstract "Background Tissue engineering techniques aim to substitute or restore the structure and function of organs and systems. The bladder has been recently considered as a promising organ for tissue engineering regeneration for augmentation or substitution. We present our experience on an experimental model and a pilot clinical study. Methods The experimental model: 10 minipigs underwent 50% volume cystectomy and bladder wall substitution using a 5 × 4 cm acellular intestinal submucosa membrane as graft, covered by omentum. In 4 pigs, autologous stem cells, bone marrow-derived, were injected into the scaffold. The animals were sacrificed at 5 weeks, and 3 months from grafting. The clinical study: 5 exstrophic patients, 8–17 years old (mean 10.4 years), presenting poor bladder capacity and compliance after bladder closure and urethra-genitalia reconstruction, who refused enterocystoplasty received intestinal submucosa membrane (cm 5 × 4) bladder grafting. Follow-up lasted 3 years. Results All animals but 1 survived. The regenerated bladders had normal capacity. The newly developed wall was lined by normal looking mucosa. At histology, 3 layers were well defined: urothelium (inner), fibrocells and muscular cells within rich connective tissue (intermediate) and a well vascularized adventitial coat. No residual scaffold was observed at 3 months. The muscular component was 28% in the engineered bladder wall, versus 44% in the native wall (p<0.05). In the clinical study at 6 months' follow-up, bladder capacity increased from 102 mls to 136 mls (mean). The difference was significant (p<0.05). At biopsy, the newly generated bladder wall appeared similar to the animal model histology. No complications occurred, but 2 patients required enterocystoplasty at 3 years' follow-up. Conclusions Bladder regeneration is feasible by tissue engineering techniques in animal models and in humans. Functional and histological results are not as with normal bladder wall. Further improvements are necessary before any extensive clinical application." @default.
- W1998511394 created "2016-06-24" @default.
- W1998511394 creator A5016068141 @default.
- W1998511394 creator A5045994087 @default.
- W1998511394 creator A5063634540 @default.
- W1998511394 creator A5075772732 @default.
- W1998511394 creator A5083346713 @default.
- W1998511394 creator A5084916468 @default.
- W1998511394 date "2012-10-01" @default.
- W1998511394 modified "2023-09-25" @default.
- W1998511394 title "Bladder Bioengineering: Our Experience" @default.
- W1998511394 cites W1503012697 @default.
- W1998511394 cites W1591007782 @default.
- W1998511394 cites W1991445463 @default.
- W1998511394 cites W1992344285 @default.
- W1998511394 cites W1997930794 @default.
- W1998511394 cites W2024244262 @default.
- W1998511394 cites W2050690282 @default.
- W1998511394 cites W2062375346 @default.
- W1998511394 cites W2086708312 @default.
- W1998511394 cites W2106416525 @default.
- W1998511394 cites W2152056221 @default.
- W1998511394 cites W2165372239 @default.
- W1998511394 doi "https://doi.org/10.5301/ru.2012.9985" @default.
- W1998511394 hasPublicationYear "2012" @default.
- W1998511394 type Work @default.
- W1998511394 sameAs 1998511394 @default.
- W1998511394 citedByCount "0" @default.
- W1998511394 crossrefType "journal-article" @default.
- W1998511394 hasAuthorship W1998511394A5016068141 @default.
- W1998511394 hasAuthorship W1998511394A5045994087 @default.
- W1998511394 hasAuthorship W1998511394A5063634540 @default.
- W1998511394 hasAuthorship W1998511394A5075772732 @default.
- W1998511394 hasAuthorship W1998511394A5083346713 @default.
- W1998511394 hasAuthorship W1998511394A5084916468 @default.
- W1998511394 hasConcept C121608353 @default.
- W1998511394 hasConcept C126322002 @default.
- W1998511394 hasConcept C126894567 @default.
- W1998511394 hasConcept C136229726 @default.
- W1998511394 hasConcept C141071460 @default.
- W1998511394 hasConcept C171056886 @default.
- W1998511394 hasConcept C2775910329 @default.
- W1998511394 hasConcept C2777085111 @default.
- W1998511394 hasConcept C2777540882 @default.
- W1998511394 hasConcept C2778702563 @default.
- W1998511394 hasConcept C2779052585 @default.
- W1998511394 hasConcept C2779762690 @default.
- W1998511394 hasConcept C2780352672 @default.
- W1998511394 hasConcept C49892992 @default.
- W1998511394 hasConcept C71924100 @default.
- W1998511394 hasConcept C86803240 @default.
- W1998511394 hasConcept C95444343 @default.
- W1998511394 hasConceptScore W1998511394C121608353 @default.
- W1998511394 hasConceptScore W1998511394C126322002 @default.
- W1998511394 hasConceptScore W1998511394C126894567 @default.
- W1998511394 hasConceptScore W1998511394C136229726 @default.
- W1998511394 hasConceptScore W1998511394C141071460 @default.
- W1998511394 hasConceptScore W1998511394C171056886 @default.
- W1998511394 hasConceptScore W1998511394C2775910329 @default.
- W1998511394 hasConceptScore W1998511394C2777085111 @default.
- W1998511394 hasConceptScore W1998511394C2777540882 @default.
- W1998511394 hasConceptScore W1998511394C2778702563 @default.
- W1998511394 hasConceptScore W1998511394C2779052585 @default.
- W1998511394 hasConceptScore W1998511394C2779762690 @default.
- W1998511394 hasConceptScore W1998511394C2780352672 @default.
- W1998511394 hasConceptScore W1998511394C49892992 @default.
- W1998511394 hasConceptScore W1998511394C71924100 @default.
- W1998511394 hasConceptScore W1998511394C86803240 @default.
- W1998511394 hasConceptScore W1998511394C95444343 @default.
- W1998511394 hasIssue "4" @default.
- W1998511394 hasLocation W19985113941 @default.
- W1998511394 hasOpenAccess W1998511394 @default.
- W1998511394 hasPrimaryLocation W19985113941 @default.
- W1998511394 hasRelatedWork W1484184588 @default.
- W1998511394 hasRelatedWork W1536598886 @default.
- W1998511394 hasRelatedWork W1990352238 @default.
- W1998511394 hasRelatedWork W1991445463 @default.
- W1998511394 hasRelatedWork W1997930794 @default.
- W1998511394 hasRelatedWork W1998040030 @default.
- W1998511394 hasRelatedWork W2008492180 @default.
- W1998511394 hasRelatedWork W2078734566 @default.
- W1998511394 hasRelatedWork W2157738808 @default.
- W1998511394 hasRelatedWork W2197571607 @default.
- W1998511394 hasVolume "79" @default.
- W1998511394 isParatext "false" @default.
- W1998511394 isRetracted "false" @default.
- W1998511394 magId "1998511394" @default.
- W1998511394 workType "article" @default.