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• W1998517993 abstract "AimsTo examine the effect of the TIMP-2 G-418C polymorphism on gastric cancer risk.MethodsWe conducted a hospital-based, case–control study using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method in 412 individuals (206 gastric cancer patients and 206 age, sex matched cancer-free controls).ResultsThe genotype and allele frequencies were significantly different (P=0.007 and 0.005, respectively) between cases and controls. Further analysis showed that the variant TIMP-2 genotypes (CC+GC) had a 51% increased risk of gastric cancer compared with GG [adjusted odds ratio (OR) 1.51, 95% confidence interval (CI) 1.00–2.26, P=0.049]. The elevated gastric cancer risk was especially evident in younger individuals (age<58 years old) (adjusted OR 2.21, 95% CI 1.18–4.16) and smokers (adjusted OR 2.61, 95% CI 1.01–6.72). However, no significant association was observed between the variant genotypes and clinicopathological features of gastric cancer.ConclusionsThese findings suggest that the TIMP-2 G-418C polymorphism is a genetic predisposing factor for gastric cancer." @default.
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• W1998517993 date "2008-06-01" @default.
• W1998517993 modified "2023-10-17" @default.
• W1998517993 title "Tissue inhibitor of metalloproteinase-2 G-418C polymorphism is associated with an increased risk of gastric cancer in a Chinese population" @default.
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• W1998517993 doi "https://doi.org/10.1016/j.ejso.2007.09.003" @default.
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