Matches in SemOpenAlex for { <https://semopenalex.org/work/W199852707> ?p ?o ?g. }
- W199852707 endingPage "1606" @default.
- W199852707 startingPage "1596" @default.
- W199852707 abstract "Research Article1 April 1996free access Cell type-specific inhibition of p53-mediated apoptosis by mdm2. Y. Haupt Y. Haupt Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Search for more papers by this author Y. Barak Y. Barak Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Search for more papers by this author M. Oren M. Oren Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Search for more papers by this author Y. Haupt Y. Haupt Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Search for more papers by this author Y. Barak Y. Barak Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Search for more papers by this author M. Oren M. Oren Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Search for more papers by this author Author Information Y. Haupt1, Y. Barak1 and M. Oren1 1Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. The EMBO Journal (1996)15:1596-1606https://doi.org/10.1002/j.1460-2075.1996.tb00504.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The effect of excess mdm2 on p53-mediated apoptosis was investigated in two human-derived cell lines, H1299 and HeLa. In H1299 cells, overexpression of mdm2 resulted in effective protection from apoptosis. This protective effect was seen only under conditions allowing the formation of p53-Mdm2 complexes. In contrast, excess mdm2 failed to abolish p53-mediated apoptosis in HeLa cells, despite a complete abrogation of p53-dependent sequence-specific transcriptional activation (SST). These data strongly support the contention that SST is dispensable for at least some types of p53-mediated apoptosis. Further, they suggest that one of the roles of mdm2 may be to modulate the apoptotic activity of p53, in a manner which is dictated by the pathway through which p53 induced apoptosis in a given cell type Previous ArticleNext Article Volume 15Issue 71 April 1996In this issue RelatedDetailsLoading ..." @default.
- W199852707 created "2016-06-24" @default.
- W199852707 creator A5035937627 @default.
- W199852707 creator A5036387444 @default.
- W199852707 creator A5038674601 @default.
- W199852707 date "1996-04-01" @default.
- W199852707 modified "2023-10-16" @default.
- W199852707 title "Cell type-specific inhibition of p53-mediated apoptosis by mdm2." @default.
- W199852707 cites W1444355571 @default.
- W199852707 cites W1481400971 @default.
- W199852707 cites W1487724525 @default.
- W199852707 cites W1490290866 @default.
- W199852707 cites W1498586399 @default.
- W199852707 cites W1501273614 @default.
- W199852707 cites W1501970115 @default.
- W199852707 cites W1510257230 @default.
- W199852707 cites W1525939857 @default.
- W199852707 cites W1528748302 @default.
- W199852707 cites W1554072136 @default.
- W199852707 cites W1564956131 @default.
- W199852707 cites W1574341547 @default.
- W199852707 cites W1576330810 @default.
- W199852707 cites W1581523186 @default.
- W199852707 cites W1591281137 @default.
- W199852707 cites W1599295812 @default.
- W199852707 cites W168561149 @default.
- W199852707 cites W1800030959 @default.
- W199852707 cites W1822460389 @default.
- W199852707 cites W1823168351 @default.
- W199852707 cites W1846012397 @default.
- W199852707 cites W1857008528 @default.
- W199852707 cites W1858648870 @default.
- W199852707 cites W1861504067 @default.
- W199852707 cites W1965173366 @default.
- W199852707 cites W1972376460 @default.
- W199852707 cites W1978400153 @default.
- W199852707 cites W1981391513 @default.
- W199852707 cites W1989936068 @default.
- W199852707 cites W1993864973 @default.
- W199852707 cites W2003282728 @default.
- W199852707 cites W2008301561 @default.
- W199852707 cites W2009745999 @default.
- W199852707 cites W2012053348 @default.
- W199852707 cites W2013330927 @default.
- W199852707 cites W2015026645 @default.
- W199852707 cites W2015519364 @default.
- W199852707 cites W2016107093 @default.
- W199852707 cites W2021326683 @default.
- W199852707 cites W2024894759 @default.
- W199852707 cites W2032911567 @default.
- W199852707 cites W2034177818 @default.
- W199852707 cites W2039382131 @default.
- W199852707 cites W2045086385 @default.
- W199852707 cites W2048783543 @default.
- W199852707 cites W2057397700 @default.
- W199852707 cites W2058737236 @default.
- W199852707 cites W2063158632 @default.
- W199852707 cites W2064194464 @default.
- W199852707 cites W2064441863 @default.
- W199852707 cites W2067368732 @default.
- W199852707 cites W2070061120 @default.
- W199852707 cites W2072763798 @default.
- W199852707 cites W2074114480 @default.
- W199852707 cites W2074451679 @default.
- W199852707 cites W2081290278 @default.
- W199852707 cites W2089218510 @default.
- W199852707 cites W2090025028 @default.
- W199852707 cites W2091151265 @default.
- W199852707 cites W2099907467 @default.
- W199852707 cites W2102930268 @default.
- W199852707 cites W2117802418 @default.
- W199852707 cites W2120483508 @default.
- W199852707 cites W2124052729 @default.
- W199852707 cites W2125297918 @default.
- W199852707 cites W2129866793 @default.
- W199852707 cites W2131670375 @default.
- W199852707 cites W2135192417 @default.
- W199852707 cites W2135535670 @default.
- W199852707 cites W2137124052 @default.
- W199852707 cites W2138302361 @default.
- W199852707 cites W2142304480 @default.
- W199852707 cites W2145596465 @default.
- W199852707 cites W2147242002 @default.
- W199852707 cites W2149287328 @default.
- W199852707 cites W2149703879 @default.
- W199852707 cites W2150583263 @default.
- W199852707 cites W2157721629 @default.
- W199852707 cites W2158627530 @default.
- W199852707 cites W2164908109 @default.
- W199852707 cites W2169600394 @default.
- W199852707 cites W2170494099 @default.
- W199852707 cites W2223661640 @default.
- W199852707 cites W2289050278 @default.
- W199852707 cites W2305591919 @default.
- W199852707 cites W2407124373 @default.
- W199852707 cites W2409183498 @default.
- W199852707 cites W2410485503 @default.
- W199852707 cites W2410945418 @default.