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- W1998529700 abstract "Thermal full-thickness burns involving 2 per cent of the body surface area were produced in guinea pigs. DNase- and coagulase-negative staphylococci cultured from the animals' normal bacterial flora were used as interference strain. They were applied to the burns of the test guinea pigs. As controls, guinea pigs were used, which were burned in the same way but not inoculated with the interference strain. An easily identifiable strain of Staphylococcus aureus was subsequently sprayed on the burns in some of the series. In the burns which were not sprayed with this test strain, records were kept only of spontaneously occurring Staphylococcus aureus. In all the series the animals in the test groups showed significantly less growth of Staphylococcus aureus both with respect to the percentage of positive animals and to the colony counts from these animals. Staphylococcus aureus positive guinea pigs thus were found in only 27 per cent in the test groups, but in 73 per cent of the controls. From the number of colonies per culture plate “growth scores” were calculated from 0 to 4 according to an arbitrary scale. The mean growth scores per animal of Staphylococcus aureus within the first two weeks after burning was 3.1 in the test guinea pigs and 8.8 in the controls. Possible practical consequenses of the observations made in the experiments are discussed, as for instance the possibility of bacteria belonging to the indigenous flora or other bacteria of lower pathogenicity to act as interference strains against hospital strains of pathogenic staphylococci." @default.
- W1998529700 created "2016-06-24" @default.
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- W1998529700 date "2009-08-15" @default.
- W1998529700 modified "2023-09-25" @default.
- W1998529700 title "STUDIES OF BACTERIAL INTERFERENCE IN EXPERIMENTALLY PRODUCED BURNS IN GUINEA PIGS" @default.
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- W1998529700 doi "https://doi.org/10.1111/j.1699-0463.1970.tb04266.x" @default.
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