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- W1998553661 abstract "Human β-endorphin produced a potent antinociceptive response as estimated by the tail-flick test in rats after intraventricular injection. On a molar basis, the peptide was 21 times more potent than morphine and in addition, the peptide produced morphine-like catatonia and hypothermia. These responses were blocked by naloxone. Repeated injections of the peptide induced tolerance to analgesic response, catatonia and hypothermia. Cross tolerance to morphine was also observed." @default.
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- W1998553661 date "1977-01-01" @default.
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- W1998553661 title "Human β-endorphin: Development of tolerance and behavioral activity in rats" @default.
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- W1998553661 doi "https://doi.org/10.1016/0006-291x(77)90316-3" @default.
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