FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998564562> ?p ?o ?g. }

• W1998564562 endingPage "1863" @default.
• W1998564562 startingPage "1856" @default.
• W1998564562 abstract "Cancer cells exhibit an endogenous constitutive oxidative stress higher than that of normal cells, which renders tumours vulnerable to further reactive oxygen species (ROS) production. Mitochondrial uncoupling protein 2 (UCP2) can mitigate oxidative stress by increasing the influx of protons into the mitochondrial matrix and reducing electron leakage and mitochondrial superoxide generation. Here, we demonstrate that chemical uncouplers or UCP2 over-expression strongly decrease mitochondrial superoxide induction by the anticancer drug gemcitabine (GEM) and protect cancer cells from GEM-induced apoptosis. Moreover, we show that GEM IC50 values well correlate with the endogenous level of UCP2 mRNA, suggesting a critical role for mitochondrial uncoupling in GEM resistance. Interestingly, GEM treatment stimulates UCP2 mRNA expression suggesting that mitochondrial uncoupling could have a role also in the acquired resistance to GEM. Conversely, UCP2 inhibition by genipin or UCP2 mRNA silencing strongly enhances GEM-induced mitochondrial superoxide generation and apoptosis, synergistically inhibiting cancer cell proliferation. These events are significantly reduced by the addition of the radical scavenger N-acetyl-l-cysteine or MnSOD over-expression, demonstrating a critical role of the oxidative stress. Normal primary fibroblasts are much less sensitive to GEM/genipin combination. Our results demonstrate for the first time that UCP2 has a role in cancer cell resistance to GEM supporting the development of an anti-cancer therapy based on UCP2 inhibition associated to GEM treatment." @default.
• W1998564562 created "2016-06-24" @default.
• W1998564562 creator A5014448714 @default.
• W1998564562 creator A5027603944 @default.
• W1998564562 creator A5037545172 @default.
• W1998564562 creator A5039540619 @default.
• W1998564562 creator A5040632094 @default.
• W1998564562 creator A5058548647 @default.
• W1998564562 creator A5067979740 @default.
• W1998564562 creator A5079651217 @default.
• W1998564562 date "2012-10-01" @default.
• W1998564562 modified "2023-10-14" @default.
• W1998564562 title "Role of mitochondrial uncoupling protein 2 in cancer cell resistance to gemcitabine" @default.
• W1998564562 cites W1541316156 @default.
• W1998564562 cites W1967366484 @default.
• W1998564562 cites W1970829588 @default.
• W1998564562 cites W1975765174 @default.
• W1998564562 cites W1978135805 @default.
• W1998564562 cites W1991238715 @default.
• W1998564562 cites W1992678387 @default.
• W1998564562 cites W1994191301 @default.
• W1998564562 cites W1997684038 @default.
• W1998564562 cites W1997726248 @default.
• W1998564562 cites W2011925577 @default.
• W1998564562 cites W2012099220 @default.
• W1998564562 cites W2014058353 @default.
• W1998564562 cites W2041162408 @default.
• W1998564562 cites W2058012195 @default.
• W1998564562 cites W2077506711 @default.
• W1998564562 cites W2077945404 @default.
• W1998564562 cites W2089039955 @default.
• W1998564562 cites W2095057456 @default.
• W1998564562 cites W2095287544 @default.
• W1998564562 cites W2097829773 @default.
• W1998564562 cites W2098227836 @default.
• W1998564562 cites W2104385322 @default.
• W1998564562 cites W2111889825 @default.
• W1998564562 cites W2117051942 @default.
• W1998564562 cites W2123821654 @default.
• W1998564562 cites W2129846704 @default.
• W1998564562 cites W2132826785 @default.
• W1998564562 cites W2136689463 @default.
• W1998564562 cites W2148603246 @default.
• W1998564562 cites W2156584859 @default.
• W1998564562 cites W2164193797 @default.
• W1998564562 cites W4247088117 @default.
• W1998564562 doi "https://doi.org/10.1016/j.bbamcr.2012.06.007" @default.
• W1998564562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22705884" @default.
• W1998564562 hasPublicationYear "2012" @default.
• W1998564562 type Work @default.
• W1998564562 sameAs 1998564562 @default.
• W1998564562 citedByCount "68" @default.
• W1998564562 countsByYear W19985645622012 @default.
• W1998564562 countsByYear W19985645622013 @default.
• W1998564562 countsByYear W19985645622014 @default.
• W1998564562 countsByYear W19985645622015 @default.
• W1998564562 countsByYear W19985645622016 @default.
• W1998564562 countsByYear W19985645622017 @default.
• W1998564562 countsByYear W19985645622018 @default.
• W1998564562 countsByYear W19985645622019 @default.
• W1998564562 countsByYear W19985645622020 @default.
• W1998564562 countsByYear W19985645622021 @default.
• W1998564562 countsByYear W19985645622022 @default.
• W1998564562 countsByYear W19985645622023 @default.
• W1998564562 crossrefType "journal-article" @default.
• W1998564562 hasAuthorship W1998564562A5014448714 @default.
• W1998564562 hasAuthorship W1998564562A5027603944 @default.
• W1998564562 hasAuthorship W1998564562A5037545172 @default.
• W1998564562 hasAuthorship W1998564562A5039540619 @default.
• W1998564562 hasAuthorship W1998564562A5040632094 @default.
• W1998564562 hasAuthorship W1998564562A5058548647 @default.
• W1998564562 hasAuthorship W1998564562A5067979740 @default.
• W1998564562 hasAuthorship W1998564562A5079651217 @default.
• W1998564562 hasBestOaLocation W19985645621 @default.
• W1998564562 hasConcept C121608353 @default.
• W1998564562 hasConcept C181199279 @default.
• W1998564562 hasConcept C185592680 @default.
• W1998564562 hasConcept C190283241 @default.
• W1998564562 hasConcept C2776151105 @default.
• W1998564562 hasConcept C2778175917 @default.
• W1998564562 hasConcept C2779732960 @default.
• W1998564562 hasConcept C2780795997 @default.
• W1998564562 hasConcept C2781438746 @default.
• W1998564562 hasConcept C28859421 @default.
• W1998564562 hasConcept C48349386 @default.
• W1998564562 hasConcept C54355233 @default.
• W1998564562 hasConcept C55493867 @default.
• W1998564562 hasConcept C86803240 @default.
• W1998564562 hasConcept C95444343 @default.
• W1998564562 hasConcept C96232424 @default.
• W1998564562 hasConceptScore W1998564562C121608353 @default.
• W1998564562 hasConceptScore W1998564562C181199279 @default.
• W1998564562 hasConceptScore W1998564562C185592680 @default.
• W1998564562 hasConceptScore W1998564562C190283241 @default.
• W1998564562 hasConceptScore W1998564562C2776151105 @default.
• W1998564562 hasConceptScore W1998564562C2778175917 @default.
• W1998564562 hasConceptScore W1998564562C2779732960 @default.
• W1998564562 hasConceptScore W1998564562C2780795997 @default.

• next