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- W199859269 abstract "Abstract Liver, brain and urine extracts of normal rats and of rats treated with β,β′-iminodipropionitrile (IDPN) have been analysed by separation on Dowex 50-H + resin and by paper electrophoresis and chromatography. The possibility that IDPN could be exerting its toxic effects by metabolism into 3,3′-diaminopropylamine (DAPA) with alteration in the physiological activity of spermine and spermidine was investigated. It has been shown that DAPA does not accumulate in the liver or brain following IDPN administration, and that gross alteration in the polyamine content of these tissues does not occur. The presence of an unknown ninhydrin-reacting substance was detected in the IDPN-treated rat brains. Three metabolites of IDPN were identified in the urine following IDPN treatment, namely cyanoacetic acid, β-alanine and β-aminopropionitrile. Prevention of the symptoms of IDPN poisoning with ethionine did not inhibit the formation of these metabolites or of thiocyanate." @default.
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- W199859269 date "1970-07-01" @default.
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- W199859269 title "Studies on the metabolism of β,β′-iminodipropionitrile in the rat" @default.
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- W199859269 doi "https://doi.org/10.1016/0006-2952(70)90126-7" @default.
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