Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998594530> ?p ?o ?g. }
- W1998594530 endingPage "9395" @default.
- W1998594530 startingPage "9391" @default.
- W1998594530 abstract "The marine natural product curacin A served as the lead compound for the combinatorial synthesis of 6-compound mixture libraries. Fluorous trapping with a vinyl ether tag was used to streamline purification of the heterogeneous multicomponent reaction products and provide chemically clearly defined mixtures. The screening profile of one mixture library, 17mix, was attractive enough to warrant the re-synthesis of the individual compounds, and an evaluation of their biological effects validated the composite data previously obtained on the product mixture. The most active of these compounds inhibited tubulin polymerization with an IC50 of ca. 1 μM, showed an average growth inhibition activity GI50 of ca. 250 nM, inhibited [3H]colchicine binding to tubulin, and blocked mitotic progression at nanomolar concentrations. These compounds represent some of the most potent synthetic curacin A analogues identified to date but have simplified structures, greater water solubility, and increased chemical stability." @default.
- W1998594530 created "2016-06-24" @default.
- W1998594530 creator A5018024103 @default.
- W1998594530 creator A5043589326 @default.
- W1998594530 creator A5050500168 @default.
- W1998594530 creator A5052391523 @default.
- W1998594530 creator A5058071588 @default.
- W1998594530 creator A5083828644 @default.
- W1998594530 date "2000-09-19" @default.
- W1998594530 modified "2023-10-16" @default.
- W1998594530 title "Synthesis and Biological Evaluation of a Focused Mixture Library of Analogues of the Antimitotic Marine Natural Product Curacin A" @default.
- W1998594530 cites W1966512392 @default.
- W1998594530 cites W1969396898 @default.
- W1998594530 cites W1969947880 @default.
- W1998594530 cites W1971039731 @default.
- W1998594530 cites W1976907094 @default.
- W1998594530 cites W1980441363 @default.
- W1998594530 cites W1985236957 @default.
- W1998594530 cites W1990390677 @default.
- W1998594530 cites W1991432128 @default.
- W1998594530 cites W1992690684 @default.
- W1998594530 cites W1999324708 @default.
- W1998594530 cites W2004070151 @default.
- W1998594530 cites W2004099240 @default.
- W1998594530 cites W2008657337 @default.
- W1998594530 cites W2032664251 @default.
- W1998594530 cites W2042515595 @default.
- W1998594530 cites W2055992184 @default.
- W1998594530 cites W2067278945 @default.
- W1998594530 cites W2107761754 @default.
- W1998594530 cites W2111991122 @default.
- W1998594530 cites W2124536344 @default.
- W1998594530 cites W2150438695 @default.
- W1998594530 cites W2163135480 @default.
- W1998594530 cites W2165918941 @default.
- W1998594530 cites W2224757179 @default.
- W1998594530 cites W2949427142 @default.
- W1998594530 cites W2950046323 @default.
- W1998594530 cites W2950344199 @default.
- W1998594530 cites W2951639485 @default.
- W1998594530 cites W2951712908 @default.
- W1998594530 doi "https://doi.org/10.1021/ja002213u" @default.
- W1998594530 hasPublicationYear "2000" @default.
- W1998594530 type Work @default.
- W1998594530 sameAs 1998594530 @default.
- W1998594530 citedByCount "86" @default.
- W1998594530 countsByYear W19985945302012 @default.
- W1998594530 countsByYear W19985945302013 @default.
- W1998594530 countsByYear W19985945302014 @default.
- W1998594530 countsByYear W19985945302015 @default.
- W1998594530 countsByYear W19985945302016 @default.
- W1998594530 countsByYear W19985945302017 @default.
- W1998594530 countsByYear W19985945302019 @default.
- W1998594530 countsByYear W19985945302020 @default.
- W1998594530 crossrefType "journal-article" @default.
- W1998594530 hasAuthorship W1998594530A5018024103 @default.
- W1998594530 hasAuthorship W1998594530A5043589326 @default.
- W1998594530 hasAuthorship W1998594530A5050500168 @default.
- W1998594530 hasAuthorship W1998594530A5052391523 @default.
- W1998594530 hasAuthorship W1998594530A5058071588 @default.
- W1998594530 hasAuthorship W1998594530A5083828644 @default.
- W1998594530 hasConcept C116073593 @default.
- W1998594530 hasConcept C155574463 @default.
- W1998594530 hasConcept C166940927 @default.
- W1998594530 hasConcept C178790620 @default.
- W1998594530 hasConcept C185592680 @default.
- W1998594530 hasConcept C202751555 @default.
- W1998594530 hasConcept C20418707 @default.
- W1998594530 hasConcept C21951064 @default.
- W1998594530 hasConcept C2779396153 @default.
- W1998594530 hasConcept C2780407432 @default.
- W1998594530 hasConcept C2780493264 @default.
- W1998594530 hasConcept C2909592991 @default.
- W1998594530 hasConcept C44228677 @default.
- W1998594530 hasConcept C521977710 @default.
- W1998594530 hasConcept C55493867 @default.
- W1998594530 hasConcept C71240020 @default.
- W1998594530 hasConcept C84425145 @default.
- W1998594530 hasConcept C86803240 @default.
- W1998594530 hasConcept C95444343 @default.
- W1998594530 hasConceptScore W1998594530C116073593 @default.
- W1998594530 hasConceptScore W1998594530C155574463 @default.
- W1998594530 hasConceptScore W1998594530C166940927 @default.
- W1998594530 hasConceptScore W1998594530C178790620 @default.
- W1998594530 hasConceptScore W1998594530C185592680 @default.
- W1998594530 hasConceptScore W1998594530C202751555 @default.
- W1998594530 hasConceptScore W1998594530C20418707 @default.
- W1998594530 hasConceptScore W1998594530C21951064 @default.
- W1998594530 hasConceptScore W1998594530C2779396153 @default.
- W1998594530 hasConceptScore W1998594530C2780407432 @default.
- W1998594530 hasConceptScore W1998594530C2780493264 @default.
- W1998594530 hasConceptScore W1998594530C2909592991 @default.
- W1998594530 hasConceptScore W1998594530C44228677 @default.
- W1998594530 hasConceptScore W1998594530C521977710 @default.
- W1998594530 hasConceptScore W1998594530C55493867 @default.
- W1998594530 hasConceptScore W1998594530C71240020 @default.
- W1998594530 hasConceptScore W1998594530C84425145 @default.
- W1998594530 hasConceptScore W1998594530C86803240 @default.