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- W1998601330 abstract "To the Editor. —Regarding the article by Mooradian and Wynn in the April issue of theArchives,1about discrepancies between the calculated digoxin clearance and the serum digoxin level in elderly patients, it should be no surprise that the serum digoxin levels by radioimmunoassay (RIA) were higher than expected. In the study by Erickson and Green,2analysis of human plasma supplemented by known amounts of digoxin... [by] RIA methods consistently yielded results >100%. This tendency of the RIA to produce falsely elevated levels may be related to the endogenous digoxinlike substance called endoxin,3which has been shown to be present in patients with a variety of clinical states, including renal impairment4and hypertension,5as well as in normal individuals.6Thus, the dismissal of estimates of digoxin clearance based on serum levels of digoxin by RIA (which, at least potentially, are falsely high) may" @default.
- W1998601330 created "2016-06-24" @default.
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- W1998601330 date "1987-10-01" @default.
- W1998601330 modified "2023-09-25" @default.
- W1998601330 title "Discrepancies Between the Calculated Digoxin Clearance and the Serum Digoxin Level in Elderly Patients" @default.
- W1998601330 cites W1870554052 @default.
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- W1998601330 doi "https://doi.org/10.1001/archinte.1987.00370100166035" @default.
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