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• W1998602308 abstract "This study evaluated the ameliorative potential of hydroalcoholic extract of Trichosanthes dioica root (TDA) against arsenic (As)-induced toxicity in rat brain. TDA (5 and 10 mg kg−1) was administered orally to Wistar albino rats for 20 consecutive days before oral administration of sodium arsenite (10 mg kg−1) for 8 days. Brain biochemical parameters including lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, and DNA fragmentation were determined. Pretreatment with TDA significantly and dose-dependently modulated all the antioxidative parameters and reduced DNA fragmentation in As-exposed rat brain. Data indicate that T. dioica root produced remarkable ameliorative effects against As-induced brain toxicity in rats mediated by modulation of oxidative stress." @default.
• W1998602308 created "2016-06-24" @default.
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• W1998602308 date "2012-04-01" @default.
• W1998602308 modified "2023-10-01" @default.
• W1998602308 title "Ameliorative effect<i>Trichosanthes dioica</i>root against arsenic-induced brain toxicity in albino rats" @default.
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• W1998602308 doi "https://doi.org/10.1080/02772248.2012.658663" @default.
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