FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998607564> ?p ?o ?g. }

• W1998607564 endingPage "1708" @default.
• W1998607564 startingPage "1702" @default.
• W1998607564 abstract "We report an improved tandem mass spectrometric assay for retinoic acid (RA) applicable to in vitro and in vivo biological samples. This liquid chromatography tandem mass spectrometric (LC/MS/MS) assay for direct RA quantification is the most sensitive to date, with a 62.5 attomol lower limit of detection and a linear range spanning greater than 4 orders of magnitude (from 250 attomol to 10 pmol). This assay resolves all-trans-RA (atRA) from its endogenous geometric isomers, is applicable to samples of limited size (10−20 mg of tissue), and functions with complex biological matrixes. Coefficients of variation are as follows: instrumental, ≤2.6%; intraday, 5.2% ± 0.7%; interday, 6.7% ± 0.9%. In vitro capabilities are demonstrated by quantification of endogenous RA and RA production (from retinol) in primary cultured astrocytes. Quantification of endogenous atRA and its geometric isomers in 129SV mouse serum and tissues (liver, kidney, adipose, muscle, spleen, testis, and brain) reveals in vivo utility of the assay. The ability to discriminate spatial concentrations of RA in vivo is illustrated with C57BL/6 mouse brain loci (hippocampus, cortex, olfactory bulb, thalamus, cerebellum, and striatum), as well as with Lewis rat proximal/distal mammary gland regions during various morphological stages: virgin, early pregnancy (e7), late pregnancy (e20), lactating (day 4), involuting day 1, and involuting day 11. This assay provides the sensitivity necessary for direct, endogenous RA quantification necessary to elucidate RA function, e.g., in neurogenesis, morphogenesis, and the contribution of altered RA homeostasis to diseases, such as Alzheimer's disease, type 2 diabetes, obesity, and cancer." @default.
• W1998607564 created "2016-06-24" @default.
• W1998607564 creator A5031527572 @default.
• W1998607564 creator A5066675786 @default.
• W1998607564 creator A5069095946 @default.
• W1998607564 creator A5076606477 @default.
• W1998607564 date "2008-02-06" @default.
• W1998607564 modified "2023-10-02" @default.
• W1998607564 title "Quantitative Profiling of Endogenous Retinoic Acid in Vivo and in Vitro by Tandem Mass Spectrometry" @default.
• W1998607564 cites W1751235690 @default.
• W1998607564 cites W1927684145 @default.
• W1998607564 cites W1970661735 @default.
• W1998607564 cites W1972662713 @default.
• W1998607564 cites W1976271397 @default.
• W1998607564 cites W1994819295 @default.
• W1998607564 cites W2012028995 @default.
• W1998607564 cites W2019631619 @default.
• W1998607564 cites W2020016625 @default.
• W1998607564 cites W2025824363 @default.
• W1998607564 cites W2047673461 @default.
• W1998607564 cites W2057072402 @default.
• W1998607564 cites W2064579441 @default.
• W1998607564 cites W2067732057 @default.
• W1998607564 cites W2079962655 @default.
• W1998607564 cites W2085760990 @default.
• W1998607564 cites W2089355027 @default.
• W1998607564 cites W2100202927 @default.
• W1998607564 cites W2106489915 @default.
• W1998607564 cites W2107037828 @default.
• W1998607564 cites W2107523109 @default.
• W1998607564 cites W2120140512 @default.
• W1998607564 cites W2122202553 @default.
• W1998607564 cites W2135420364 @default.
• W1998607564 cites W2136643063 @default.
• W1998607564 cites W2155409665 @default.
• W1998607564 cites W2187999838 @default.
• W1998607564 cites W2291668409 @default.
• W1998607564 cites W2312235522 @default.
• W1998607564 cites W2338210778 @default.
• W1998607564 cites W2735280994 @default.
• W1998607564 doi "https://doi.org/10.1021/ac702030f" @default.
• W1998607564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4086453" @default.
• W1998607564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18251521" @default.
• W1998607564 hasPublicationYear "2008" @default.
• W1998607564 type Work @default.
• W1998607564 sameAs 1998607564 @default.
• W1998607564 citedByCount "204" @default.
• W1998607564 countsByYear W19986075642012 @default.
• W1998607564 countsByYear W19986075642013 @default.
• W1998607564 countsByYear W19986075642014 @default.
• W1998607564 countsByYear W19986075642015 @default.
• W1998607564 countsByYear W19986075642016 @default.
• W1998607564 countsByYear W19986075642017 @default.
• W1998607564 countsByYear W19986075642018 @default.
• W1998607564 countsByYear W19986075642019 @default.
• W1998607564 countsByYear W19986075642020 @default.
• W1998607564 countsByYear W19986075642021 @default.
• W1998607564 countsByYear W19986075642022 @default.
• W1998607564 countsByYear W19986075642023 @default.
• W1998607564 crossrefType "journal-article" @default.
• W1998607564 hasAuthorship W1998607564A5031527572 @default.
• W1998607564 hasAuthorship W1998607564A5066675786 @default.
• W1998607564 hasAuthorship W1998607564A5069095946 @default.
• W1998607564 hasAuthorship W1998607564A5076606477 @default.
• W1998607564 hasBestOaLocation W19986075642 @default.
• W1998607564 hasConcept C104317684 @default.
• W1998607564 hasConcept C134018914 @default.
• W1998607564 hasConcept C150903083 @default.
• W1998607564 hasConcept C162356407 @default.
• W1998607564 hasConcept C16613235 @default.
• W1998607564 hasConcept C185592680 @default.
• W1998607564 hasConcept C207001950 @default.
• W1998607564 hasConcept C2781121885 @default.
• W1998607564 hasConcept C31827203 @default.
• W1998607564 hasConcept C43617362 @default.
• W1998607564 hasConcept C55493867 @default.
• W1998607564 hasConcept C86803240 @default.
• W1998607564 hasConceptScore W1998607564C104317684 @default.
• W1998607564 hasConceptScore W1998607564C134018914 @default.
• W1998607564 hasConceptScore W1998607564C150903083 @default.
• W1998607564 hasConceptScore W1998607564C162356407 @default.
• W1998607564 hasConceptScore W1998607564C16613235 @default.
• W1998607564 hasConceptScore W1998607564C185592680 @default.
• W1998607564 hasConceptScore W1998607564C207001950 @default.
• W1998607564 hasConceptScore W1998607564C2781121885 @default.
• W1998607564 hasConceptScore W1998607564C31827203 @default.
• W1998607564 hasConceptScore W1998607564C43617362 @default.
• W1998607564 hasConceptScore W1998607564C55493867 @default.
• W1998607564 hasConceptScore W1998607564C86803240 @default.
• W1998607564 hasIssue "5" @default.
• W1998607564 hasLocation W19986075641 @default.
• W1998607564 hasLocation W19986075642 @default.
• W1998607564 hasLocation W19986075643 @default.
• W1998607564 hasLocation W19986075644 @default.
• W1998607564 hasOpenAccess W1998607564 @default.
• W1998607564 hasPrimaryLocation W19986075641 @default.
• W1998607564 hasRelatedWork W1964002287 @default.
• W1998607564 hasRelatedWork W1970739379 @default.

• next