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- W1998609948 abstract "Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and commonly play an important role in the regulation of lipid homeostasis. Although three PPAR subtypes, alpha, delta and gamma show a relatively close amino acid sequence homology, the functions of each PPAR are distinct. For example, PPARalpha and PPARdelta induce lipid oxidation, while PPARgamma activates lipid storage and adipogenesis. To analyze the detail functions of human PPARs, we previously established tetracycline-regulated human hepatoblastoma cell lines that can be induced to express each human PPAR subtype. The expression of each PPAR subtype in established cell line was tightly controlled by the concentration of doxycycline. DNA microarray analyses using these cell lines were performed with or without adding ligand and provided the important information on the PPAR target genes. Furthermore, we analyzed the 5'-flanking region of the human adipose differentiation-related protein (adrp) gene that responded to all subtypes of PPARs, and determined the functional PPRE of the human adrp gene. Here we discuss the usefulness of these cell lines." @default.
- W1998609948 created "2016-06-24" @default.
- W1998609948 creator A5086288542 @default.
- W1998609948 date "2007-08-01" @default.
- W1998609948 modified "2023-10-04" @default.
- W1998609948 title "Application of the Human Hepatoblastoma Cell Lines Inducibly Expressing Peroxisome Proliferator-activated Receptors (PPARs)" @default.
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- W1998609948 doi "https://doi.org/10.1248/yakushi.127.1223" @default.
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