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- W1998617247 abstract "Introduction: To investigate if chromosome complement as determined by analysis of a single blastomere from a day 3 embryo by array CGH, is indicative of blastocyst developmental potential. Method: 283 day 3 embryos from 45 PGS patients were included in the study. Patients were undergoing PGS testing for a number of recognised indications such as advanced maternal age, recurrent implantation failure and recurrent miscarriage. Embryos were cultured until day 3 and a single blastomere was biopsied as per protocol using calcium/ magnesium free medium (Cook) and a laser to make a small breach in the zona. Embryos with a minimum of 5 cells were included. All cells were tubed individually and analysed using aCGH (Genesis24) for their ploidy status. Results were analysed based on initial ploidy and the rate of blastulation, and secondly to the extent of aneuploidy and the rate of blastulation. Cells with more than 4 aneuosomies were deemed to be complex aneuploid. Results were analysed using Chi squared two tailed test. Results: 58 embryos were inferred to be euploid following analysis of the blastomere. Of these 39 (67.2%) developed to blastocysts on day 5 and a further 1 by day 6 totalling a 69.0% blastocyst rate. 225 embryos were inferred to be aneuploid following aCGH testing on the blastomere; 100 (44.4%) reached a blastocyst stage by day 5 followed by a further 33 by day 6. This gave a total blastocyst rate of 59.1%. No statistical difference was seen with reference to the developmental stage of blastocysts. When analysing the extent of aneuploidy in terms of the number of chromosomes affected, a trend towards a higher blastocyst rate when fewer aneusomies were inferred from the blastomere was observed. When only one aneusomy was present, 46 of the 60 embryos developed to a blastocyst stage whereas when more than 4 aneusomies were inferred only 31 of the 92 embryos reached a blastocyst stage (p 4 aneusomies the development to blastulation is significantly decreased." @default.
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- W1998617247 date "2012-05-01" @default.
- W1998617247 modified "2023-09-24" @default.
- W1998617247 title "P29 Developmental potential of day 3 embryos diagnosed by array CGH analysis on the blastomere" @default.
- W1998617247 doi "https://doi.org/10.1016/s1472-6483(12)60246-6" @default.
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