Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998618368> ?p ?o ?g. }
- W1998618368 endingPage "1082" @default.
- W1998618368 startingPage "1069" @default.
- W1998618368 abstract "Superfamily ATPases in type IV pili, type 2 secretion, and archaella (formerly archaeal flagella) employ similar sequences for distinct biological processes. Here, we structurally and functionally characterize prototypical superfamily ATPase FlaI in Sulfolobus acidocaldarius, showing FlaI activities in archaeal swimming-organelle assembly and movement. X-ray scattering data of FlaI in solution and crystal structures with and without nucleotide reveal a hexameric crown assembly with key cross-subunit interactions. Rigid building blocks form between N-terminal domains (points) and neighboring subunit C-terminal domains (crown ring). Upon nucleotide binding, these six cross-subunit blocks move with respect to each other and distinctly from secretion and pilus ATPases. Crown interactions and conformations regulate assembly, motility, and force direction via a basic-clamp switching mechanism driving conformational changes between stable, backbone-interconnected moving blocks. Collective structural and mutational results identify in vivo functional components for assembly and motility, phosphate-triggered rearrangements by ATP hydrolysis, and molecular predictors for distinct ATPase superfamily functions." @default.
- W1998618368 created "2016-06-24" @default.
- W1998618368 creator A5000308635 @default.
- W1998618368 creator A5014373421 @default.
- W1998618368 creator A5019310643 @default.
- W1998618368 creator A5020740373 @default.
- W1998618368 creator A5038401373 @default.
- W1998618368 creator A5059713279 @default.
- W1998618368 creator A5062723541 @default.
- W1998618368 creator A5089386282 @default.
- W1998618368 date "2013-03-01" @default.
- W1998618368 modified "2023-09-29" @default.
- W1998618368 title "Insights into FlaI Functions in Archaeal Motor Assembly and Motility from Structures, Conformations, and Genetics" @default.
- W1998618368 cites W1844213024 @default.
- W1998618368 cites W1963537078 @default.
- W1998618368 cites W1965183244 @default.
- W1998618368 cites W1968429745 @default.
- W1998618368 cites W1971558825 @default.
- W1998618368 cites W1971945771 @default.
- W1998618368 cites W1980735881 @default.
- W1998618368 cites W1984530381 @default.
- W1998618368 cites W1986953176 @default.
- W1998618368 cites W1987599124 @default.
- W1998618368 cites W1988371610 @default.
- W1998618368 cites W1994595595 @default.
- W1998618368 cites W1995731582 @default.
- W1998618368 cites W2009457103 @default.
- W1998618368 cites W2011071330 @default.
- W1998618368 cites W2018786644 @default.
- W1998618368 cites W2019341121 @default.
- W1998618368 cites W2026764734 @default.
- W1998618368 cites W2028904598 @default.
- W1998618368 cites W2030517878 @default.
- W1998618368 cites W2038109524 @default.
- W1998618368 cites W2050783261 @default.
- W1998618368 cites W2062586990 @default.
- W1998618368 cites W2064202871 @default.
- W1998618368 cites W2065786781 @default.
- W1998618368 cites W2066990113 @default.
- W1998618368 cites W2073904681 @default.
- W1998618368 cites W2074109361 @default.
- W1998618368 cites W2084420243 @default.
- W1998618368 cites W2101016185 @default.
- W1998618368 cites W2104504181 @default.
- W1998618368 cites W2105021118 @default.
- W1998618368 cites W2109263298 @default.
- W1998618368 cites W2109692167 @default.
- W1998618368 cites W2112084168 @default.
- W1998618368 cites W2112799684 @default.
- W1998618368 cites W2117775711 @default.
- W1998618368 cites W2134201060 @default.
- W1998618368 cites W2134236489 @default.
- W1998618368 cites W2136521058 @default.
- W1998618368 cites W2141760967 @default.
- W1998618368 cites W2141872014 @default.
- W1998618368 cites W2142654956 @default.
- W1998618368 cites W2151460035 @default.
- W1998618368 cites W2157606315 @default.
- W1998618368 cites W2162001459 @default.
- W1998618368 cites W2163510227 @default.
- W1998618368 cites W2165999429 @default.
- W1998618368 cites W2168840243 @default.
- W1998618368 doi "https://doi.org/10.1016/j.molcel.2013.01.014" @default.
- W1998618368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3615136" @default.
- W1998618368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23416110" @default.
- W1998618368 hasPublicationYear "2013" @default.
- W1998618368 type Work @default.
- W1998618368 sameAs 1998618368 @default.
- W1998618368 citedByCount "92" @default.
- W1998618368 countsByYear W19986183682013 @default.
- W1998618368 countsByYear W19986183682014 @default.
- W1998618368 countsByYear W19986183682015 @default.
- W1998618368 countsByYear W19986183682016 @default.
- W1998618368 countsByYear W19986183682017 @default.
- W1998618368 countsByYear W19986183682018 @default.
- W1998618368 countsByYear W19986183682019 @default.
- W1998618368 countsByYear W19986183682020 @default.
- W1998618368 countsByYear W19986183682021 @default.
- W1998618368 countsByYear W19986183682022 @default.
- W1998618368 countsByYear W19986183682023 @default.
- W1998618368 crossrefType "journal-article" @default.
- W1998618368 hasAuthorship W1998618368A5000308635 @default.
- W1998618368 hasAuthorship W1998618368A5014373421 @default.
- W1998618368 hasAuthorship W1998618368A5019310643 @default.
- W1998618368 hasAuthorship W1998618368A5020740373 @default.
- W1998618368 hasAuthorship W1998618368A5038401373 @default.
- W1998618368 hasAuthorship W1998618368A5059713279 @default.
- W1998618368 hasAuthorship W1998618368A5062723541 @default.
- W1998618368 hasAuthorship W1998618368A5089386282 @default.
- W1998618368 hasBestOaLocation W19986183681 @default.
- W1998618368 hasConcept C104292427 @default.
- W1998618368 hasConcept C104317684 @default.
- W1998618368 hasConcept C115811362 @default.
- W1998618368 hasConcept C12554922 @default.
- W1998618368 hasConcept C141315368 @default.
- W1998618368 hasConcept C174832134 @default.
- W1998618368 hasConcept C181199279 @default.
- W1998618368 hasConcept C23265538 @default.