FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998641605> ?p ?o ?g. }

• W1998641605 endingPage "546" @default.
• W1998641605 startingPage "537" @default.
• W1998641605 abstract "Rab3A, a member of the Rab3 small G protein family, regulates Ca2+-dependent exocytosis of neurotransmitter. The cyclical activation and inactivation of Rab3A are essential for the Rab3A action in exocytosis. GDP-Rab3A is activated to GTP-Rab3A by Rab3 GDP/GTP exchange protein (Rab3 GEP) and GTP-Rab3A is inactivated to GDP-Rab3A by Rab3 GTPase-activating protein (Rab3 GAP). We have recently found a novel protein, named rabconnectin-3, which is co-immunoprecipitated with Rab3 GEP or GAP from the extract of the crude synaptic vesicle (CSV) fraction of rat brain. Rabconnectin-3 is abundantly expressed in the brain where it is associated with synaptic vesicles. We have found that two more proteins are co-immunoprecipitated with Rab3 GEP from the CSV fraction of rat brain. We attempted here to isolate and characterize one of them.We determined its partial amino acid sequence, cloned its cDNA from a human cDNA library, and determined its primary structure. The protein consisted of 1490 amino acids (aa) and showed a calculated molecular weight of 163808. The protein had 7 WD domains. The protein was abundantly expressed in the brain where it co-localized with rabconnectin-3 on synaptic vesicles. The protein formed a stable complex with rabconnectin-3. We named this protein rabconnectin-3beta and renamed rabconnectin-3 rabconnectin-3alpha. Rabconnectin-3beta, but not rabconnectin-3alpha, directly bound Rab3 GEP. Neither rabconnectin-3alpha nor -3beta directly bound Rab3 GAP.These results indicate that rabconnectin-3 consists of the alpha and beta subunits and binds directly Rab3 GEP through the beta subunit and indirectly Rab3 GAP through an unidentified molecule(s)." @default.
• W1998641605 created "2016-06-24" @default.
• W1998641605 creator A5001030503 @default.
• W1998641605 creator A5003522677 @default.
• W1998641605 creator A5008622181 @default.
• W1998641605 creator A5018506413 @default.
• W1998641605 creator A5021178886 @default.
• W1998641605 creator A5033375456 @default.
• W1998641605 creator A5042331400 @default.
• W1998641605 creator A5045852979 @default.
• W1998641605 creator A5074742463 @default.
• W1998641605 creator A5082461054 @default.
• W1998641605 date "2003-06-01" @default.
• W1998641605 modified "2023-10-11" @default.
• W1998641605 title "A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca²⁺-dependent exocytosis of neurotransmitter" @default.
• W1998641605 cites W1511501308 @default.
• W1998641605 cites W1553798208 @default.
• W1998641605 cites W1973653941 @default.
• W1998641605 cites W1990720057 @default.
• W1998641605 cites W1993285794 @default.
• W1998641605 cites W2024625520 @default.
• W1998641605 cites W2045659151 @default.
• W1998641605 cites W2045941756 @default.
• W1998641605 cites W2062226079 @default.
• W1998641605 cites W2063057624 @default.
• W1998641605 cites W2064148637 @default.
• W1998641605 cites W2065039468 @default.
• W1998641605 cites W2067722891 @default.
• W1998641605 cites W2081174927 @default.
• W1998641605 cites W2082587873 @default.
• W1998641605 cites W2098145494 @default.
• W1998641605 cites W2100837269 @default.
• W1998641605 cites W2108943672 @default.
• W1998641605 cites W2111778006 @default.
• W1998641605 cites W2333989636 @default.
• W1998641605 cites W4293247451 @default.
• W1998641605 doi "https://doi.org/10.1046/j.1365-2443.2003.00655.x" @default.
• W1998641605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12786944" @default.
• W1998641605 hasPublicationYear "2003" @default.
• W1998641605 type Work @default.
• W1998641605 sameAs 1998641605 @default.
• W1998641605 citedByCount "48" @default.
• W1998641605 countsByYear W19986416052012 @default.
• W1998641605 countsByYear W19986416052013 @default.
• W1998641605 countsByYear W19986416052014 @default.
• W1998641605 countsByYear W19986416052015 @default.
• W1998641605 countsByYear W19986416052016 @default.
• W1998641605 countsByYear W19986416052017 @default.
• W1998641605 countsByYear W19986416052019 @default.
• W1998641605 countsByYear W19986416052020 @default.
• W1998641605 countsByYear W19986416052021 @default.
• W1998641605 countsByYear W19986416052022 @default.
• W1998641605 countsByYear W19986416052023 @default.
• W1998641605 crossrefType "journal-article" @default.
• W1998641605 hasAuthorship W1998641605A5001030503 @default.
• W1998641605 hasAuthorship W1998641605A5003522677 @default.
• W1998641605 hasAuthorship W1998641605A5008622181 @default.
• W1998641605 hasAuthorship W1998641605A5018506413 @default.
• W1998641605 hasAuthorship W1998641605A5021178886 @default.
• W1998641605 hasAuthorship W1998641605A5033375456 @default.
• W1998641605 hasAuthorship W1998641605A5042331400 @default.
• W1998641605 hasAuthorship W1998641605A5045852979 @default.
• W1998641605 hasAuthorship W1998641605A5074742463 @default.
• W1998641605 hasAuthorship W1998641605A5082461054 @default.
• W1998641605 hasBestOaLocation W19986416051 @default.
• W1998641605 hasConcept C104317684 @default.
• W1998641605 hasConcept C118716 @default.
• W1998641605 hasConcept C130316041 @default.
• W1998641605 hasConcept C148785051 @default.
• W1998641605 hasConcept C156728348 @default.
• W1998641605 hasConcept C167625842 @default.
• W1998641605 hasConcept C175969161 @default.
• W1998641605 hasConcept C181199279 @default.
• W1998641605 hasConcept C187882448 @default.
• W1998641605 hasConcept C207332259 @default.
• W1998641605 hasConcept C41625074 @default.
• W1998641605 hasConcept C49039625 @default.
• W1998641605 hasConcept C55493867 @default.
• W1998641605 hasConcept C62478195 @default.
• W1998641605 hasConcept C71829478 @default.
• W1998641605 hasConcept C80631254 @default.
• W1998641605 hasConcept C85771745 @default.
• W1998641605 hasConcept C86803240 @default.
• W1998641605 hasConcept C95444343 @default.
• W1998641605 hasConceptScore W1998641605C104317684 @default.
• W1998641605 hasConceptScore W1998641605C118716 @default.
• W1998641605 hasConceptScore W1998641605C130316041 @default.
• W1998641605 hasConceptScore W1998641605C148785051 @default.
• W1998641605 hasConceptScore W1998641605C156728348 @default.
• W1998641605 hasConceptScore W1998641605C167625842 @default.
• W1998641605 hasConceptScore W1998641605C175969161 @default.
• W1998641605 hasConceptScore W1998641605C181199279 @default.
• W1998641605 hasConceptScore W1998641605C187882448 @default.
• W1998641605 hasConceptScore W1998641605C207332259 @default.
• W1998641605 hasConceptScore W1998641605C41625074 @default.
• W1998641605 hasConceptScore W1998641605C49039625 @default.
• W1998641605 hasConceptScore W1998641605C55493867 @default.
• W1998641605 hasConceptScore W1998641605C62478195 @default.

• next