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- W1998642021 abstract "Krox-20, a C<sub>2</sub>H<sub>2</sub>-type zinc-finger transcription factor, plays an important role in rhombomere development. This study reveals that the <i>Krox-20</i> null mutation impacts the development of mesencephalic trigeminal (Me5) neurons, a cell group traditionally thought to emerge from the mesencephalon. Based on cell counting studies, we show that <i>Krox-20</i> null mutants have twice as many Me5 neurons relative to wildtypes at E15, but by birth have half the number of Me5 cells as wildtypes. TUNEL studies reveal a period of increased apoptosis from E17-P0 in mutants. The mutation does not result in differences in Me5 cell size, morphology, gene expression or peripheral projection patterns between genotypes, as demonstrated by retrograde tracing and Brn3a immunohistochemistry. The data suggest that Krox-20 regulates the period and extent of Me5 apoptosis, impacting the final number of Me5 neurons. The loss of Me5 in <i>Krox-20<sup>–/–</sup></i> mice may highlight species-specific differences in the origin of these cells." @default.
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- W1998642021 date "2005-01-01" @default.
- W1998642021 modified "2023-09-23" @default.
- W1998642021 title "Mesencephalic Trigeminal Nucleus Development Is Dependent on Krox-20 Expression" @default.
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- W1998642021 doi "https://doi.org/10.1159/000084532" @default.
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