Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998647130> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W1998647130 endingPage "52" @default.
- W1998647130 startingPage "49" @default.
- W1998647130 abstract "For decades, warfarin has been the gold standard anticoagulant that is recommended in patients with atrial fibrillation for the prevention of stroke and systemic embolic events. However, warfarin therapy has several disadvantages; including significant risks of bleeding, a narrow therapeutic margin necessitating frequent monitoring and interactions with numerous drugs and foods. These limitations created a need for safer, more convenient alternative anticoagulants for stroke prevention. Ximelagatran (Exanta™, Astrazeneca) is a novel, oral direct thrombin inhibitor that inhibits the final step in the coagulation process, namely, the conversion of fibrinogen to insoluble fibrin by thrombin. It has a rapid onset of action, a relatively wide therapeutic margin and a low potential for food and drug interactions. In addition, it can be administered in a fixed dosage, which obviates the need for anticoagulation monitoring, thus simplifying treatment and improving compliance. The Stroke Prevention Using Oral Thrombin Inhibitor in Atrial Fibrillation (SPORTIF) program has been investigating the safety and efficacy of ximelagatran for the prevention of stroke in patients with AF. This report discusses the implications of the recently published Phase III trial, SPORTIF III, which evaluated the efficacy and safety of ximelagatran as compared with warfarin in high-risk patients with AF." @default.
- W1998647130 created "2016-06-24" @default.
- W1998647130 creator A5034469027 @default.
- W1998647130 date "2004-09-01" @default.
- W1998647130 modified "2023-09-25" @default.
- W1998647130 title "Ximelagatran for stroke prevention in atrial fibrillation" @default.
- W1998647130 cites W1978506115 @default.
- W1998647130 cites W1983866419 @default.
- W1998647130 cites W2076391495 @default.
- W1998647130 cites W4239134555 @default.
- W1998647130 doi "https://doi.org/10.2217/14750708.1.1.49" @default.
- W1998647130 hasPublicationYear "2004" @default.
- W1998647130 type Work @default.
- W1998647130 sameAs 1998647130 @default.
- W1998647130 citedByCount "0" @default.
- W1998647130 crossrefType "journal-article" @default.
- W1998647130 hasAuthorship W1998647130A5034469027 @default.
- W1998647130 hasConcept C126322002 @default.
- W1998647130 hasConcept C127413603 @default.
- W1998647130 hasConcept C164705383 @default.
- W1998647130 hasConcept C2776301958 @default.
- W1998647130 hasConcept C2778810321 @default.
- W1998647130 hasConcept C2779161974 @default.
- W1998647130 hasConcept C2779630707 @default.
- W1998647130 hasConcept C2780645631 @default.
- W1998647130 hasConcept C71924100 @default.
- W1998647130 hasConcept C78519656 @default.
- W1998647130 hasConceptScore W1998647130C126322002 @default.
- W1998647130 hasConceptScore W1998647130C127413603 @default.
- W1998647130 hasConceptScore W1998647130C164705383 @default.
- W1998647130 hasConceptScore W1998647130C2776301958 @default.
- W1998647130 hasConceptScore W1998647130C2778810321 @default.
- W1998647130 hasConceptScore W1998647130C2779161974 @default.
- W1998647130 hasConceptScore W1998647130C2779630707 @default.
- W1998647130 hasConceptScore W1998647130C2780645631 @default.
- W1998647130 hasConceptScore W1998647130C71924100 @default.
- W1998647130 hasConceptScore W1998647130C78519656 @default.
- W1998647130 hasIssue "1" @default.
- W1998647130 hasLocation W19986471301 @default.
- W1998647130 hasOpenAccess W1998647130 @default.
- W1998647130 hasPrimaryLocation W19986471301 @default.
- W1998647130 hasRelatedWork W184589437 @default.
- W1998647130 hasRelatedWork W1967841144 @default.
- W1998647130 hasRelatedWork W1995818964 @default.
- W1998647130 hasRelatedWork W1997088717 @default.
- W1998647130 hasRelatedWork W2124882362 @default.
- W1998647130 hasRelatedWork W2170786340 @default.
- W1998647130 hasRelatedWork W2272431884 @default.
- W1998647130 hasRelatedWork W2319489406 @default.
- W1998647130 hasRelatedWork W2763816051 @default.
- W1998647130 hasRelatedWork W4236955258 @default.
- W1998647130 hasVolume "1" @default.
- W1998647130 isParatext "false" @default.
- W1998647130 isRetracted "false" @default.
- W1998647130 magId "1998647130" @default.
- W1998647130 workType "article" @default.