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- W1998651013 abstract "This paper summarizes a series of electrophysiological studies aimed at finding the effects of the activation of 5-HT(7) receptors on neuronal excitability as well as on excitatory and inhibitory synaptic transmission in the hippocampus and in the frontal cortex of the rat. These studies demonstrated that 5-HT(7) receptors play an important role in the modulation of the activity of the hippocampal network by regulating the excitability of pyramidal cells of the CA1 area, as well as via their effect on GABA and glutamatergic transmission. The reactivity of 5-HT(7) receptors in the hippocampus is decreased by repeated administration of antidepressant drugs and increased by a prolonged high level of corticosterone. More importantly, administration of antidepressant drug, imipramine, prevents the occurrence of corticosterone-induced changes in the function of hippocampal 5-HT(7) receptors. It has also been found that the blockade of 5-HT(7) receptors by the selective antagonist SB 269970, lasting for a few days, causes similar changes to those observed after long-term administration of antidepressants. Thus, it seems that the pharmacological blockade of 5-HT(7) receptors produces faster effects compared to classic antidepressant drugs. A similarity between the changes in the glutamatergic transmission induced by the blockade of 5 HT7 receptors and those caused by repeated administration of the antidepressant drug, imipramine, has also been found in the frontal cortex. It has also been shown that the changes in glutamatergic transmission and the impairment of long-term synaptic plasticity in the frontal cortex of animals subjected to repeated restraint stress are reversed by the blockade of 5-HT(7) receptors. Overall, these studies, together with the data provided by other investigators, support the hypothesis that 5-HT(7) receptor antagonists may become a prototype of a new class of antidepressant drugs. Such compounds will not function by blocking 5-HT reuptake, as many of the currently used drugs, but through a direct interaction with the 5-HT(7) receptor. This type of action is highly selective and usually does not require the occurrence of adaptive changes in neuronal functions, thus allowing for a much quicker therapeutic effect." @default.
- W1998651013 created "2016-06-24" @default.
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- W1998651013 date "2012-11-01" @default.
- W1998651013 modified "2023-10-12" @default.
- W1998651013 title "Stress- and antidepressant treatment-induced modifications of 5-HT7 receptor functions in the rat brain" @default.
- W1998651013 cites W1509868652 @default.
- W1998651013 cites W1524125780 @default.
- W1998651013 cites W1524618747 @default.
- W1998651013 cites W1565257873 @default.
- W1998651013 cites W1604949247 @default.
- W1998651013 cites W1828538530 @default.
- W1998651013 cites W1928141651 @default.
- W1998651013 cites W1966819687 @default.
- W1998651013 cites W1967261577 @default.
- W1998651013 cites W1975490671 @default.
- W1998651013 cites W1975970107 @default.
- W1998651013 cites W1977170740 @default.
- W1998651013 cites W1978891587 @default.
- W1998651013 cites W1982008289 @default.
- W1998651013 cites W1984829646 @default.
- W1998651013 cites W1985615482 @default.
- W1998651013 cites W1986150116 @default.
- W1998651013 cites W1989830384 @default.
- W1998651013 cites W1993236628 @default.
- W1998651013 cites W1993358982 @default.
- W1998651013 cites W1994768475 @default.
- W1998651013 cites W1999399598 @default.
- W1998651013 cites W1999919402 @default.
- W1998651013 cites W2000288557 @default.
- W1998651013 cites W2001304703 @default.
- W1998651013 cites W2004479769 @default.
- W1998651013 cites W2007816528 @default.
- W1998651013 cites W2007895617 @default.
- W1998651013 cites W2009304697 @default.
- W1998651013 cites W2011188320 @default.
- W1998651013 cites W2011750343 @default.
- W1998651013 cites W2012729010 @default.
- W1998651013 cites W2012737748 @default.
- W1998651013 cites W2014001501 @default.
- W1998651013 cites W2020674121 @default.
- W1998651013 cites W2022279290 @default.
- W1998651013 cites W2023928627 @default.
- W1998651013 cites W2024469079 @default.
- W1998651013 cites W2029680769 @default.
- W1998651013 cites W2029881647 @default.
- W1998651013 cites W2030424446 @default.
- W1998651013 cites W2030646640 @default.
- W1998651013 cites W2030812260 @default.
- W1998651013 cites W2038293241 @default.
- W1998651013 cites W2038567085 @default.
- W1998651013 cites W2040903359 @default.
- W1998651013 cites W2046326428 @default.
- W1998651013 cites W2048995786 @default.
- W1998651013 cites W2054235103 @default.
- W1998651013 cites W2058644057 @default.
- W1998651013 cites W2058651616 @default.
- W1998651013 cites W2060267954 @default.
- W1998651013 cites W2060589548 @default.
- W1998651013 cites W2063928651 @default.
- W1998651013 cites W2064669765 @default.
- W1998651013 cites W2066701183 @default.
- W1998651013 cites W2066831309 @default.
- W1998651013 cites W2069175484 @default.
- W1998651013 cites W2070941417 @default.
- W1998651013 cites W2075675414 @default.
- W1998651013 cites W2078090509 @default.
- W1998651013 cites W2080461836 @default.
- W1998651013 cites W2080705534 @default.
- W1998651013 cites W2081659500 @default.
- W1998651013 cites W2085977381 @default.
- W1998651013 cites W2086305648 @default.
- W1998651013 cites W2087467518 @default.
- W1998651013 cites W2088081549 @default.
- W1998651013 cites W2088577867 @default.
- W1998651013 cites W2089421079 @default.
- W1998651013 cites W2092499931 @default.
- W1998651013 cites W2093255864 @default.
- W1998651013 cites W2093358121 @default.
- W1998651013 cites W2093431980 @default.
- W1998651013 cites W2093475197 @default.
- W1998651013 cites W2094573117 @default.
- W1998651013 cites W2101287902 @default.
- W1998651013 cites W2102312968 @default.
- W1998651013 cites W2102438497 @default.
- W1998651013 cites W2102660603 @default.
- W1998651013 cites W2103880802 @default.
- W1998651013 cites W2106623141 @default.
- W1998651013 cites W2113624561 @default.
- W1998651013 cites W2128411608 @default.
- W1998651013 cites W2131553858 @default.
- W1998651013 cites W2131914725 @default.
- W1998651013 cites W2143787546 @default.
- W1998651013 cites W2148975835 @default.