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- W1998664384 abstract "A series of small model complexes made from NiII and the ligands ethylenediamine (en), histamine (hist), and histidylleucine (HisLeu) were prepared and studied as potential hydrolytic DNA-cleavage agents. The stability constants and species-distribution curves for these complexes were determined as a function of pH. The 1 : 1 : 1 ternary complexes [NiII(en)(HisLeu)] (1) and [NiII(hist)(HisLeu)] (2) were the only major species present at the physiologically relevant pH of 6–7, as further corroborated by ESI-MS analysis. The complex geometries of 1 and 2 were analyzed by UV/VIS experiments and molecular dynamics (MD) simulations. Both ternary complexes were found to intercalate with DNA, as shown by UV/VIS, thermal-denaturation, and fluorescence-titration studies with ethidium bromide (EB). The intrinsic binding constants (Kb) for the bound complexes 1⋅DNA and 2⋅DNA were determined as 150 and 290, resp. Gel-electrophoresis experiments revealed that 1 and 2 cleave supercoiled (type-I) to nicked-circular (type-II) DNA at physiological pH, with rate constants of 0.64 and 0.75 h−1, resp. A tentative mechanism for this hydrolytic cleavage is proposed." @default.
- W1998664384 created "2016-06-24" @default.
- W1998664384 creator A5041414963 @default.
- W1998664384 creator A5064691861 @default.
- W1998664384 date "2006-02-01" @default.
- W1998664384 modified "2023-10-18" @default.
- W1998664384 title "Ternary Nickel(II) Complexes as Hydrolytic DNA-Cleavage Agents" @default.
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- W1998664384 doi "https://doi.org/10.1002/cbdv.200690027" @default.
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