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• W1998669871 abstract "The total synthesis and in vitro activities of a series of chemical inducers of dimerization (CIDs) is described. The use of small-molecule CIDs to control the dimerization of engineered FKBP12-containing fusion proteins has been demonstrated to have broad utility in biological research as well as potential medical applications in gene and cell therapies. The facility and flexibility of preparation make this new class of wholly synthetic compounds exceptionally versatile tools for the study of intracellular signaling events mediated by protein–protein interactions or protein localization. While some congeners possess potency comparable to or better than the first generation natural product-derived CID, FK1012, structure–activity relationships are complex and underscore the need for application-specific compound optimizations." @default.
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• W1998669871 date "1998-08-01" @default.
• W1998669871 modified "2023-10-16" @default.
• W1998669871 title "Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins" @default.
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• W1998669871 doi "https://doi.org/10.1016/s0968-0896(98)00125-4" @default.
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