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- W1998679999 endingPage "939" @default.
- W1998679999 startingPage "929" @default.
- W1998679999 abstract "Current pathophysiological theories of schizophrenia highlight the role of altered brain connectivity. This dysconnectivity could manifest 1) anatomically, through structural changes of association fibers at the cellular level, and/or 2) functionally, through aberrant control of synaptic plasticity at the synaptic level. In this article, we review the evidence for these theories, focusing on the modulation of synaptic plasticity. In particular, we discuss how dysconnectivity, observed between brain regions in schizophrenic patients, could result from abnormal modulation of N-methyl-D-aspartate (NMDA)-dependent plasticity by other neurotransmitter systems. We focus on the implication of the dysconnection hypothesis for functional imaging at the systems level. In particular, we review recent advances in measuring plasticity in the human brain using functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) that can be used to address dysconnectivity in schizophrenia. Promising experimental paradigms include perceptual and reinforcement learning. We describe how theoretical and causal models of brain responses might contribute to a mechanistic understanding of synaptic plasticity in schizophrenia." @default.
- W1998679999 created "2016-06-24" @default.
- W1998679999 creator A5016719332 @default.
- W1998679999 creator A5046016423 @default.
- W1998679999 creator A5086852785 @default.
- W1998679999 date "2006-05-01" @default.
- W1998679999 modified "2023-09-30" @default.
- W1998679999 title "Synaptic Plasticity and Dysconnection in Schizophrenia" @default.
- W1998679999 cites W1248076745 @default.
- W1998679999 cites W1259888278 @default.
- W1998679999 cites W144271823 @default.
- W1998679999 cites W1499820341 @default.
- W1998679999 cites W1572640432 @default.
- W1998679999 cites W1578782149 @default.
- W1998679999 cites W1607957700 @default.
- W1998679999 cites W1963673462 @default.
- W1998679999 cites W1963942033 @default.
- W1998679999 cites W1971452505 @default.
- W1998679999 cites W1971758547 @default.
- W1998679999 cites W1974262619 @default.
- W1998679999 cites W1975168383 @default.
- W1998679999 cites W1976532093 @default.
- W1998679999 cites W1978054437 @default.
- W1998679999 cites W1978538293 @default.
- W1998679999 cites W1981404361 @default.
- W1998679999 cites W1982142654 @default.
- W1998679999 cites W1988486070 @default.
- W1998679999 cites W1990431336 @default.
- W1998679999 cites W1991664166 @default.
- W1998679999 cites W1993049854 @default.
- W1998679999 cites W1995275991 @default.
- W1998679999 cites W1996141026 @default.
- W1998679999 cites W2000558224 @default.
- W1998679999 cites W2001486260 @default.
- W1998679999 cites W2002692727 @default.
- W1998679999 cites W2005044038 @default.
- W1998679999 cites W2005583506 @default.
- W1998679999 cites W2006883575 @default.
- W1998679999 cites W2008716335 @default.
- W1998679999 cites W2009362065 @default.
- W1998679999 cites W2011459890 @default.
- W1998679999 cites W2012410605 @default.
- W1998679999 cites W2014276443 @default.
- W1998679999 cites W2019532214 @default.
- W1998679999 cites W2020939800 @default.
- W1998679999 cites W2022044536 @default.
- W1998679999 cites W2023199657 @default.
- W1998679999 cites W2027691566 @default.
- W1998679999 cites W2029059267 @default.
- W1998679999 cites W2029410109 @default.
- W1998679999 cites W2031304721 @default.
- W1998679999 cites W2032208151 @default.
- W1998679999 cites W2035322026 @default.
- W1998679999 cites W2044829843 @default.
- W1998679999 cites W2045834656 @default.
- W1998679999 cites W2045916872 @default.
- W1998679999 cites W2048541312 @default.
- W1998679999 cites W2049428801 @default.
- W1998679999 cites W2053287773 @default.
- W1998679999 cites W2053850015 @default.
- W1998679999 cites W2057565196 @default.
- W1998679999 cites W2057749702 @default.
- W1998679999 cites W2058053468 @default.
- W1998679999 cites W2059752408 @default.
- W1998679999 cites W2061637827 @default.
- W1998679999 cites W2062674478 @default.
- W1998679999 cites W2062861273 @default.
- W1998679999 cites W2063341859 @default.
- W1998679999 cites W2063669117 @default.
- W1998679999 cites W2067646093 @default.
- W1998679999 cites W2068980337 @default.
- W1998679999 cites W2071090720 @default.
- W1998679999 cites W2073223573 @default.
- W1998679999 cites W2073642024 @default.
- W1998679999 cites W2075674145 @default.
- W1998679999 cites W2079608357 @default.
- W1998679999 cites W2086817748 @default.
- W1998679999 cites W2088080264 @default.
- W1998679999 cites W2088605934 @default.
- W1998679999 cites W2090356423 @default.
- W1998679999 cites W2090916846 @default.
- W1998679999 cites W2091898010 @default.
- W1998679999 cites W2091956502 @default.
- W1998679999 cites W2092516689 @default.
- W1998679999 cites W2092610789 @default.
- W1998679999 cites W2095587053 @default.
- W1998679999 cites W2095774626 @default.
- W1998679999 cites W2097609425 @default.
- W1998679999 cites W2098391962 @default.
- W1998679999 cites W2105962778 @default.
- W1998679999 cites W2109848582 @default.
- W1998679999 cites W2109884388 @default.
- W1998679999 cites W2110496616 @default.
- W1998679999 cites W2111627644 @default.
- W1998679999 cites W2112927743 @default.
- W1998679999 cites W2115460562 @default.
- W1998679999 cites W2117663940 @default.
- W1998679999 cites W2118176757 @default.